Source:http://linkedlifedata.com/resource/umls/id/C0017354
MSH: Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.,CSP: any gene in which a mutation will result in the premature death of the organism carrying it.