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rdf:type |
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skos:definition |
MSH: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.,CSP: pyrimidine analog that is an antineoplastic antimetabolite.,NCI: A drug used to treat symptoms of cancer of the colon, breast, stomach, and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite.,PDQ: An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, r
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skos:inScheme |
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skos:broader |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R28409625,
http://linkedlifedata.com/resource/umls/relation/R112184054,
http://linkedlifedata.com/resource/umls/relation/R28482967,
http://linkedlifedata.com/resource/umls/relation/R112184070,
http://linkedlifedata.com/resource/umls/relation/R49862716,
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http://linkedlifedata.com/resource/umls/relation/R55154298,
http://linkedlifedata.com/resource/umls/relation/R112185399,
http://linkedlifedata.com/resource/umls/relation/R32101756,
http://linkedlifedata.com/resource/umls/relation/R32101757,
http://linkedlifedata.com/resource/umls/relation/R32101758,
http://linkedlifedata.com/resource/umls/relation/R32101759,
http://linkedlifedata.com/resource/umls/relation/R32101760,
http://linkedlifedata.com/resource/umls/relation/R32101761,
http://linkedlifedata.com/resource/umls/relation/R32101762,
http://linkedlifedata.com/resource/umls/relation/R44807706,
http://linkedlifedata.com/resource/umls/relation/R44807718,
http://linkedlifedata.com/resource/umls/relation/R44807717,
http://linkedlifedata.com/resource/umls/relation/R44807707,
http://linkedlifedata.com/resource/umls/relation/R44807708,
http://linkedlifedata.com/resource/umls/relation/R44807709
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