Cycloleucine

Source:http://linkedlifedata.com/resource/umls/id/C0010575

MSH: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.,CHV: a kind of amino acid,PDQ: A synthetic amino acid derivative of cyclopentanecarboxylic acid, cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39200&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C404" NCI Thesaurus),NCI: A no

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