| umls-concept:C0009077 | skos:definition | MSH: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.,NCI: A semisynthetic beta-lactamase resistant penicillin antibiotic with antibacterial activity. Cloxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall, thereby preventing the cross-linkage of peptidoglycans, which are critical components of the bacterial cell wall. This leads to an interruption of the bacterial cell wall and causes bacterial cell lysis. | lld:umls |
