Source:http://linkedlifedata.com/resource/umls/id/C0008381
MSH: A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.,NCI: Encoded by human CYP11A1 Gene (Cytochrome P450 Family), 521-aa 60-kDa (precursor) Cytochrome P450C11A1 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase that catalyzes a side-chain cleavage reaction conversion of cholesterol to pregnenolone, the first (rate-limiting) step in the synthesis of steroid hormones. CYP11A1 defects cause congenital adrenal insufficiency (CAI) and congenital lipoid adrenal hyperplasia (CLAH). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)