| umls-concept:C0007036 | skos:definition | MSH: A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.,CSP: any substance or agent which suppresses, prevents or opposes the activity of carbonic anhydrase by decreasing hydrogen ion concentrations in the renal tubules, and increasing excretion of sodium, potassium, bicarbonate, and water.,NCI: Any substance that inhibits carbonate dehydratase (carbonic anhydrase), an enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Carbonic anhydrases play important roles in mineral and metabolic homeostasis. | lld:umls |
