Source:http://linkedlifedata.com/resource/umls/id/C0004006
MSH: An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.,NCI: Human CAD Gene (DHOase Family) encodes a trifunctional homohexameric cytoplasmic 2225-aa 243-kDa protein associated with the first 3 enzymatic activities of the 6-step de novo pyrimidine nucleotide biosynthesis pathway: Carbamoylphosphate Synthetase (GD-CPSASE), Aspartate Carbamoyltransferase, and Dihydroorotase, containing a CPSase domain and a type-1 glutamine amidotransferase domain. PRPP is a CAD activator and UMP is an inhibitor of CPSase. CAD is directly regulated allosterically by phosphorylation from the MAPK cascade.