| umls-concept:C0000545 | skos:definition | NCI: An essential, polyunsaturated, 20-carbon omega-3 fatty acid with anti-inflammatory and potential antineoplastic and chemopreventive activities. Eicosapentaenoic acid (EPA) may activate caspase 3, resulting in apoptosis in susceptible tumor cell populations. In addition, this agent may inhibit cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin synthesis and prostaglandin-mediated inflammatory processes.,NCI: A class of polyunsaturated fatty acids with 20 carbons and 5 double bonds.,NCI: Polyunsaturated fatty acid with 20 carbons and 5 double bonds at the 3rd, 6th, 9th, 12th and 15th carbons from the methyl end.,NCI: A polyunsaturated long-chain fatty acid with a 20-carbon backbone and 5 double bonds, originating from the 3rd, 6th, 9th, 12th and 15th positions from the methyl end.,MSH: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, r | lld:umls |
