Source:http://linkedlifedata.com/resource/umls/id/C0000294
MSH: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.,NCI: A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.,CSP: 2-mercaptoethanesulfonic acid sodium salt; scavenges glutathione; used as a detoxifying agent for uroprotection (especially in cancer combination chemotherapy), as a prophlylactic for hemorrhagic cystitis, and as an expectorant in treating chronic bronchitis.,PDQ: A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=3975