| pubmed-article:9987015 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0596630 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:9987015 | lifeskim:mentions | umls-concept:C1707723 | lld:lifeskim |
| pubmed-article:9987015 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9987015 | pubmed:dateCreated | 1999-4-1 | lld:pubmed |
| pubmed-article:9987015 | pubmed:abstractText | The role of protein kinase C (PKC) in the control of neurotransmitter release from cultured rat cerebellar granule cells was investigated. Release of preloaded [3H]-D-aspartate which is incorporated into synaptic vesicles in this preparation was evoked by electrical field stimulation or elevated KCl. PKC activation by phorbol esters resulted in a large facilitation of field-evoked Ca(2+)-dependent [3H]-D-aspartate release and a lesser enhancement of KCl-stimulated release. Inhibition of PKC by Ro 31-8220 or staurosporine virtually abolished field-evoked release but had no effect on KCl-evoked release. Field-evoked, but not KCl-evoked, synaptic vesicle exocytosis monitored by the fluorescent vesicle probe FM2-10 was inhibited by staurosporine. PKC was not directly modulating neurite Ca2+ channels coupled to release, as Ro 31-8220 did not inhibit these channels. Activation or inhibition of PKC modulated field-evoked plasma membrane depolarization, but had no effect on KCl-evoked depolarization, consistent with a regulation of Na+ or K+ channels activated by field stimulation. No modulation of field-evoked neurite Na+ influx was seen using phorbol esters. Phorbol ester-induced facilitation of field-evoked [3H]-D-aspartate release and neurite Ca2+ entry was non-additive with that produced by the specific K+ channel antagonist dendrotoxin-1, suggesting that PKC modulates transmitter release from field-stimulated cerebellar granule cells by inhibiting a dendrotoxin-1-sensitive K+ channel. | lld:pubmed |
| pubmed-article:9987015 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9987015 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9987015 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9987015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9987015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9987015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9987015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9987015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9987015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9987015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9987015 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9987015 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9987015 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:9987015 | pubmed:author | pubmed-author:NichollsD GDG | lld:pubmed |
| pubmed-article:9987015 | pubmed:author | pubmed-author:McLaughlinMM | lld:pubmed |
| pubmed-article:9987015 | pubmed:author | pubmed-author:CousinM AMA | lld:pubmed |
| pubmed-article:9987015 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9987015 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9987015 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9987015 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9987015 | pubmed:pagination | 101-9 | lld:pubmed |
| pubmed-article:9987015 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9987015 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9987015 | pubmed:articleTitle | Protein kinase C modulates field-evoked transmitter release from cultured rat cerebellar granule cells via a dendrotoxin-sensitive K+ channel. | lld:pubmed |
| pubmed-article:9987015 | pubmed:affiliation | Department of Pharmacology and Neuroscience, Ninewells Medical School, University of Dundee, UK. mcousin@cmri.usyd.edu.au | lld:pubmed |
| pubmed-article:9987015 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9987015 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9987015 | lld:pubmed |
