| pubmed-article:9971916 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C2348693 | lld:lifeskim |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:9971916 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9971916 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9971916 | pubmed:dateCreated | 1999-4-13 | lld:pubmed |
| pubmed-article:9971916 | pubmed:abstractText | Permeability coefficients for 114 compounds across excised human skin in vitro were taken from Kirchner et al. Forty-seven descriptors were calculated encompassing the relevant physicochemical parameters of the compounds. Quantitative structure-permeability relationships (QSPRs) were developed using least-squares regression analysis. A two-parameter QSPR, describing the permeability coefficients (Kp) across excised skin, was obtained: log Kp=0.772 log P -0.0103 Mr - 2.33 where log P is the logarithm of the octanol-water partition coefficient and Mr is molecular mass. This equation indicates that percutaneous absorption is mediated by the hydrophobicity and the molecular size of the penetrant. Comparison with a QSPR based on penetration across a synthetic (polydimethylsiloxane) membrane suggests that the mechanisms of drug flux across polydimethylsiloxane membranes and excised human skin are significantly different. | lld:pubmed |
| pubmed-article:9971916 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9971916 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9971916 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9971916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9971916 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9971916 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9971916 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:9971916 | pubmed:issn | 0928-0987 | lld:pubmed |
| pubmed-article:9971916 | pubmed:author | pubmed-author:DeardenJ CJC | lld:pubmed |
| pubmed-article:9971916 | pubmed:author | pubmed-author:MossG PGP | lld:pubmed |
| pubmed-article:9971916 | pubmed:author | pubmed-author:CroninM TMT | lld:pubmed |
| pubmed-article:9971916 | pubmed:author | pubmed-author:Murray-Dickso... | lld:pubmed |
| pubmed-article:9971916 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9971916 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:9971916 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9971916 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9971916 | pubmed:pagination | 325-30 | lld:pubmed |
| pubmed-article:9971916 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:meshHeading | pubmed-meshheading:9971916-... | lld:pubmed |
| pubmed-article:9971916 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9971916 | pubmed:articleTitle | Investigation of the mechanism of flux across human skin in vitro by quantitative structure-permeability relationships. | lld:pubmed |
| pubmed-article:9971916 | pubmed:affiliation | School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK. m.t.cronin@livjm.ac.uk | lld:pubmed |
| pubmed-article:9971916 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9971916 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9971916 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9971916 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9971916 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9971916 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9971916 | lld:pubmed |
