| pubmed-article:9931093 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9931093 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:9931093 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9931093 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9931093 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9931093 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9931093 | pubmed:dateCreated | 1999-2-19 | lld:pubmed |
| pubmed-article:9931093 | pubmed:abstractText | -Tacrolimus (FK 506) is a powerful, widely used immunosuppressant. The clinical utility of FK 506 is complicated by substantial hypertension and nephrotoxicity. To clarify the mechanisms of FK 506-induced hypertension, we studied the chronic effects of FK 506 on the synthesis of endothelin-1 (ET-1), the expression of mRNA of ET-1 and endothelin-converting enzyme-1 (ECE-1), the endothelial nitric oxide synthase (eNOS) activity, and the expression of mRNA of eNOS and C-type natriuretic peptide (CNP) in rat blood vessels. In addition, the effect of the specific endothelin type A receptor antagonist FR 139317 on FK 506-induced hypertension in rats was studied. FK 506, 5 mg. kg-1. d-1 given for 4 weeks, elevated blood pressure from 102+/-13 to 152+/-15 mm Hg and increased the synthesis of ET-1 and the levels of ET-1 mRNA in the mesenteric artery (240% and 230%, respectively). Little change was observed in the expression of ECE-1 mRNA and CNP mRNA. FK 506 decreased eNOS activity and the levels of eNOS mRNA in the aorta (48% and 55%, respectively). The administration of FR 139317 (10 mg. kg-1. d-1) prevented FK 506-induced hypertension in rats. These results indicate that FK 506 may increase blood pressure not only by increasing ET-1 production but also by decreasing NO synthesis in the vasculature. | lld:pubmed |
| pubmed-article:9931093 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9931093 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9931093 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9931093 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9931093 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9931093 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9931093 | pubmed:issn | 0194-911X | lld:pubmed |
| pubmed-article:9931093 | pubmed:author | pubmed-author:TakedaYY | lld:pubmed |
| pubmed-article:9931093 | pubmed:author | pubmed-author:FurukawaKK | lld:pubmed |
| pubmed-article:9931093 | pubmed:author | pubmed-author:MabuchiHH | lld:pubmed |
| pubmed-article:9931093 | pubmed:author | pubmed-author:InabaSS | lld:pubmed |
| pubmed-article:9931093 | pubmed:author | pubmed-author:MiyamoriII | lld:pubmed |
| pubmed-article:9931093 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9931093 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:9931093 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9931093 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9931093 | pubmed:pagination | 130-6 | lld:pubmed |
| pubmed-article:9931093 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9931093 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9931093 | pubmed:articleTitle | Mechanisms of FK 506-induced hypertension in the rat. | lld:pubmed |
| pubmed-article:9931093 | pubmed:affiliation | Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan. takeday@mhs.mp.kanazawa-u.ac.jp | lld:pubmed |
| pubmed-article:9931093 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9931093 | pubmed:publicationType | Comparative Study | lld:pubmed |
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