Linked Life Data

9930632

Source:http://linkedlifedata.com/resource/pubmed/id/9930632

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pubmed-article:9930632pubmed:abstractTextThe aim of this study was to assess the GH-IGFI axis, GH receptor availability, as reflected by the levels of GH-BP, and the amount of GH-dependent IGFBP-3 in adult IDDM patients with different degrees of metabolic control. Thus, 10 adult well-controlled IDDMs (HbA1 7.8 +/- 0.4%), 10 adult non-ketotic poorly controlled IDDMs (HbA1 13.3 +/- 7%) and 14 sex- and age-matched healthy controls were subjected to two intravenous GH-RH stimulation tests with 0.1 and 1.0 microg/kg body weight respectively, and a plasma IGF-1 generation test induced by the administration of hGH. Poorly controlled IDDM patients exhibited an exaggerated GH response to 1.0 microg/kg of GH-RH when compared to healthy control subjects. Low fasting plasma IGF-1 levels and a blunted IGF-1 response to exogenously administered hGH were also found in poorly controlled IDDMs when compared to the healthy control group. GH-BP levels were significantly lower in IDDMs than in normal controls, and correlated positively with the IGF-1 generation capacity after hGH. Serum IGFBP-3 levels measured by RIA were similar in IDDM and control groups. Good glycemic control for 5.7 +/- 0.9 months did not correct the above mentioned abnormalities of the GH-IGF-1 axis. Our findings suggest that IDDM is associated with a diminished availability of GH receptors and synthesis of IGF-1. GH might then increase as a compensatory mechanism, further down-regulating liver GH receptors, and thus perpetuating the initial abnormality.lld:pubmed
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pubmed-article:9930632pubmed:authorpubmed-author:GutmanR ARAlld:pubmed
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pubmed-article:9930632pubmed:dateRevised2009-2-19lld:pubmed
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pubmed-article:9930632pubmed:year1998lld:pubmed
pubmed-article:9930632pubmed:articleTitleGrowth hormone-insulin-like growth factor-I axis in adult insulin-dependent diabetic patients: evidence for central hypersensitivity to growth hormone-releasing hormone and peripheral resistance to growth hormone.lld:pubmed
pubmed-article:9930632pubmed:affiliationDivision of Endocrinology and Nuclear Medicine, Hospital Italiano de Buenos Aires, Argentina. pfainstein@intramed.net.arlld:pubmed
pubmed-article:9930632pubmed:publicationTypeJournal Articlelld:pubmed