| pubmed-article:990715 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:990715 | lifeskim:mentions | umls-concept:C0011849 | lld:lifeskim |
| pubmed-article:990715 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:990715 | lifeskim:mentions | umls-concept:C0314657 | lld:lifeskim |
| pubmed-article:990715 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:990715 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:990715 | pubmed:issue | 6040 | lld:pubmed |
| pubmed-article:990715 | pubmed:dateCreated | 1977-1-25 | lld:pubmed |
| pubmed-article:990715 | pubmed:abstractText | Two hundred and eighty-eight patients with insulin-dependent diabetes w,o were aged 30 or under at onset and 150 patients with late-onset diabetes, 50 of them dependent on insulin and 100 not dependent on insulin, were HLA-typed. There was a significant positive association between the young-onset insulin-dependent patients and HLA-B8, BW15, and B18 and a significant negative association with B7. These data were combined with those from two other centres. There was a significant concordance for the distribution of all the HLA antigens among these three series, producing evidence in favour of an HLA-linked diabetogenic gene (or genes) having a major role in all cases of juvenile-onset insulin-dependent diabetes. There was a positive association between late-onset insulin-dependent diabetes and B8, but no association between non-insulin-dependent diabetes and the HLA system. This provides further evidence for the existence of different pathogenetic mechanisms in the two major clinical forms of diabetes mellitus. | lld:pubmed |
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| pubmed-article:990715 | pubmed:language | eng | lld:pubmed |
| pubmed-article:990715 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:990715 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:990715 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:990715 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:990715 | pubmed:issn | 0007-1447 | lld:pubmed |
| pubmed-article:990715 | pubmed:author | pubmed-author:WoodrowJ CJC | lld:pubmed |
| pubmed-article:990715 | pubmed:author | pubmed-author:CudworthA GAG | lld:pubmed |
| pubmed-article:990715 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:990715 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:990715 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:990715 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:990715 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:990715 | pubmed:pagination | 846-8 | lld:pubmed |
| pubmed-article:990715 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:990715 | pubmed:year | 1976 | lld:pubmed |
| pubmed-article:990715 | pubmed:articleTitle | Genetic susceptibility in diabetes mellitus: analysis of the HLA association. | lld:pubmed |
| pubmed-article:990715 | pubmed:publicationType | Journal Article | lld:pubmed |
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