| pubmed-article:9890937 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9890937 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:9890937 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:9890937 | lifeskim:mentions | umls-concept:C0033640 | lld:lifeskim |
| pubmed-article:9890937 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:9890937 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9890937 | pubmed:dateCreated | 1999-2-16 | lld:pubmed |
| pubmed-article:9890937 | pubmed:abstractText | The phosphorylation state of three identified neural-specific protein kinase C substrates (RC3, GAP-43/B-50, and MARCKS) was monitored in hippocampal slices of mice lacking the gamma-subtype of protein kinase C and wild-type controls by quantitative immunoprecipitation following 32Pi labeling. Depolarization with potassium, activation of glutamate receptors with glutamate, or direct stimulation of protein kinase C with a phorbol ester increased RC3 phosphorylation in wild-type animals but failed to affect RC3 phosphorylation in mice lacking the gamma-subtype of protein kinase C. Our results suggests the following biochemical pathway: activation of a postsynaptic (metabotropic) glutamate receptor stimulates the gamma-subtype of protein kinase C, which in turn phosphorylates RC3. The inability to increase RC3 phosphorylation in mice lacking the gamma-subtype of protein kinase C by membrane depolarization or glutamate receptor activation may contribute to the spatial learning deficits and impaired hippocampal LTP observed in these mice. | lld:pubmed |
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| pubmed-article:9890937 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9890937 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9890937 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9890937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9890937 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9890937 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9890937 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9890937 | pubmed:author | pubmed-author:de GraanP NPN | lld:pubmed |
| pubmed-article:9890937 | pubmed:author | pubmed-author:RamakersG MGM | lld:pubmed |
| pubmed-article:9890937 | pubmed:author | pubmed-author:GerendasyD... | lld:pubmed |
| pubmed-article:9890937 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9890937 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:9890937 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:9890937 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9890937 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9890937 | pubmed:pagination | 1873-4 | lld:pubmed |
| pubmed-article:9890937 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:9890937 | pubmed:meshHeading | pubmed-meshheading:9890937-... | lld:pubmed |
| pubmed-article:9890937 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9890937 | pubmed:articleTitle | Substrate phosphorylation in the protein kinase Cgamma knockout mouse. | lld:pubmed |
| pubmed-article:9890937 | pubmed:affiliation | Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Unversiteitsweg 100, 3584 CG Utrecht, The Netherlands. geert.ramakers@basalmed.uio.no | lld:pubmed |
| pubmed-article:9890937 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9890937 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9890937 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9890937 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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