| pubmed-article:9887113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9887113 | lifeskim:mentions | umls-concept:C0579233 | lld:lifeskim |
| pubmed-article:9887113 | lifeskim:mentions | umls-concept:C0034052 | lld:lifeskim |
| pubmed-article:9887113 | lifeskim:mentions | umls-concept:C0006100 | lld:lifeskim |
| pubmed-article:9887113 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9887113 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9887113 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9887113 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9887113 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9887113 | pubmed:dateCreated | 1999-3-15 | lld:pubmed |
| pubmed-article:9887113 | pubmed:abstractText | To study whether a sepsis-induced increase in des-Arg9-bradykinin (des-Arg9-BK) and bradykinin (BK) B1-receptor activity participates in the observed increase in pulmonary vascular resistance in neonatal group B streptococcal sepsis (GBS), isometric force bioassays of pulmonary artery (PA) rings were studied, after 4-h exposure to either Krebs or GBS, by using the following protocols: 1) BK dose-response curve, 2) vascular response to BK with NG-nitro-L-arginine methyl ester (L-NAME), and 3) response to des-Arg9-BK (BK metabolite and B1 agonist). PA rings exposed to BK resulted in contraction in the GBS group and a decrease in resting tension in the Control group (P = 0.034) at a concentration of 10(-5) M. GBS-treated PA rings contracted more to des-Arg9-BK than did Controls (P < 0.001). BK (10(-6) M) relaxed preconstricted PA rings incubated in GBS less than BK relaxed Controls (P < 0.001), and preincubation with L-NAME decreased relaxation in both. These results suggest that GBS decreased endothelium-dependent BK relaxation and increased contractile response to des-Arg9-BK. We speculate that this occurs secondary to upregulation of B1 receptors reflected by B1-agonist-mediated PA contraction. | lld:pubmed |
| pubmed-article:9887113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9887113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9887113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9887113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9887113 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9887113 | pubmed:issn | 8750-7587 | lld:pubmed |
| pubmed-article:9887113 | pubmed:author | pubmed-author:GoldbergR NRN | lld:pubmed |
| pubmed-article:9887113 | pubmed:author | pubmed-author:Van BreemenCC | lld:pubmed |
| pubmed-article:9887113 | pubmed:author | pubmed-author:HerbertDD | lld:pubmed |
| pubmed-article:9887113 | pubmed:author | pubmed-author:LaskeyRR | lld:pubmed |
| pubmed-article:9887113 | pubmed:author | pubmed-author:WhitehurstR... | lld:pubmed |
| pubmed-article:9887113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9887113 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:9887113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9887113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9887113 | pubmed:pagination | 61-5 | lld:pubmed |
| pubmed-article:9887113 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:meshHeading | pubmed-meshheading:9887113-... | lld:pubmed |
| pubmed-article:9887113 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9887113 | pubmed:articleTitle | Influence of group B streptococci on piglet pulmonary artery response to bradykinin. | lld:pubmed |
| pubmed-article:9887113 | pubmed:affiliation | Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101, USA. | lld:pubmed |
| pubmed-article:9887113 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9887113 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:9887113 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
