| pubmed-article:9882319 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C2718295 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C1422036 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9882319 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9882319 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9882319 | pubmed:dateCreated | 1999-2-18 | lld:pubmed |
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| pubmed-article:9882319 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9882319 | pubmed:abstractText | The multiple sclerosis-associated retrovirus (MSRV) isolated from plasma of MS patients was found to be phylogenetically and experimentally related to human endogenous retroviruses (HERVs). To characterize the MSRV-related HERV family and to test the hypothesis of a replication-competent HERV, we have investigated the expression of MSRV-related sequences in healthy tissues. The expression of MSRV-related transcripts restricted to the placenta led to the isolation of overlapping cDNA clones from a cDNA library. These cDNAs spanned a 7.6-kb region containing gag, pol, and env genes; RU5 and U3R flanking sequences; a polypurine tract; and a primer binding site (PBS). As this PBS showed similarity to avian retrovirus PBSs used by tRNATrp, this new HERV family was named HERV-W. Several genomic elements were identified, one of them containing a complete HERV-W unit, spanning all cDNA clones. Elements of this multicopy family were not replication competent, as gag and pol open reading frames (ORFs) were interrupted by frameshifts and stop codons. A complete ORF putatively coding for an envelope protein was found both on the HERV-W DNA prototype and within an RU5-env-U3R polyadenylated cDNA clone. Placental expression of 8-, 3.1-, and 1.3-kb transcripts was observed, and a putative splicing strategy was described. The apparently tissue-restricted HERV-W long terminal repeat expression is discussed with respect to physiological and pathological contexts. | lld:pubmed |
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| pubmed-article:9882319 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9882319 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9882319 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9882319 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9882319 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9882319 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9882319 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9882319 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9882319 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:MallerDD | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:PerrotFF | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:BlondJ LJL | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:MandrandBB | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:DuretLL | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:BesèmeFF | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:BoutonOO | lld:pubmed |
| pubmed-article:9882319 | pubmed:author | pubmed-author:BedinFF | lld:pubmed |
| pubmed-article:9882319 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9882319 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:9882319 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9882319 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9882319 | pubmed:pagination | 1175-85 | lld:pubmed |
| pubmed-article:9882319 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9882319 | pubmed:meshHeading | pubmed-meshheading:9882319-... | lld:pubmed |
| pubmed-article:9882319 | pubmed:meshHeading | pubmed-meshheading:9882319-... | lld:pubmed |
