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pubmed-article:9873712pubmed:abstractTextA series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C-terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several compounds of the series were shown to be orally bioavailable.lld:pubmed
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pubmed-article:9873712pubmed:articleTitleAryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors.lld:pubmed
pubmed-article:9873712pubmed:affiliationDepartment 47J, AP-10, Abbott Laboratory, Abbott Park, Illinois 60064, USA.lld:pubmed
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