Linked Life Data

9873492

Source:http://linkedlifedata.com/resource/pubmed/id/9873492

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pubmed-article:9873492pubmed:abstractTextThe wide ranging marine sponge Hyrtios erecta is the source of the spongistatins, a new class of macrocyclic lactone antineoplastic agents. Continuation of a detailed investigation of cancer cell growth inhibitory (P388 lymphocytic leukemia) fractions (trace) from H. erecta has revealed the presence (10(-5) to 10(-7)% yield) of cytotoxic pentacyclic sesterterpenes. Employing P388 leukemia and human tumor cell line-guided bioassay techniques, two new moderate inhibitors of cancer cells were isolated and named sesterstatins 4 (1a, P388 ED50 4.9 micrograms/mL) and 5 (1b, DU-145 prostate GI50 1.9 micrograms/mL). Similar to other sesterterpenes, sesterstatin 5 inhibited growth of a Gram-positive bacterium. High field (500 MHz) 2-D NMR techniques were primarily employed for initial structural assignments, and structural assignments were confirmed by X-ray crystal structure determination of sesterstatin 4 (1a) and 5 (1b).lld:pubmed
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pubmed-article:9873492pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9873492pubmed:year1998lld:pubmed
pubmed-article:9873492pubmed:articleTitleAntineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives).lld:pubmed
pubmed-article:9873492pubmed:affiliationCancer Research Institute, Arizona State University, Tempe 85287-2404, USA.lld:pubmed
pubmed-article:9873492pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9873492pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:9873492pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
pubmed-article:9873492pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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