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pubmed-article:9873379pubmed:abstractText13-Dehydro derivatives of prostaglandin E1, E2, E3, F1 alpha and F2 alpha were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.lld:pubmed
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pubmed-article:9873379pubmed:articleTitleSynthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins.lld:pubmed
pubmed-article:9873379pubmed:affiliationResearch Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.lld:pubmed
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