| pubmed-article:9870344 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9870344 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9870344 | lifeskim:mentions | umls-concept:C0596002 | lld:lifeskim |
| pubmed-article:9870344 | lifeskim:mentions | umls-concept:C0025242 | lld:lifeskim |
| pubmed-article:9870344 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:9870344 | lifeskim:mentions | umls-concept:C0205122 | lld:lifeskim |
| pubmed-article:9870344 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9870344 | pubmed:dateCreated | 1999-6-11 | lld:pubmed |
| pubmed-article:9870344 | pubmed:abstractText | Studies in rats have shown that the polysynaptic flexor reflex (FR) but not the monosynaptic reflexes are affected by N-methyl-D-aspartate (NMDA) receptor antagonists. Theoretically, the suppression of FR might be caused by an alteration of the spinal nociceptive neurons. To investigate, whether the non-competitive NMDA receptor antagonist memantine interferes with nociception in man, we studied both its effect on pain perception and on FR. In a double-blind study 14 male subjects were randomly assigned to either placebo or memantine (30 mg p.o.) treatment. H-reflex (HR) and FR as well as pain and tolerance threshold were determined prior to and 6 h after drug intake. Contrary to expectations, there were no differential treatment effects either on FR threshold and magnitude or on pain and tolerance thresholds or the HR amplitude. | lld:pubmed |
| pubmed-article:9870344 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9870344 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9870344 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9870344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9870344 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9870344 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9870344 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9870344 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:9870344 | pubmed:author | pubmed-author:DichgansJJ | lld:pubmed |
| pubmed-article:9870344 | pubmed:author | pubmed-author:LöschmannP... | lld:pubmed |
| pubmed-article:9870344 | pubmed:author | pubmed-author:KlockgetherTT | lld:pubmed |
| pubmed-article:9870344 | pubmed:author | pubmed-author:SchugensM MMM | lld:pubmed |
| pubmed-article:9870344 | pubmed:author | pubmed-author:SchepelmannKK | lld:pubmed |
| pubmed-article:9870344 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9870344 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:9870344 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:9870344 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9870344 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9870344 | pubmed:pagination | 159-61 | lld:pubmed |
| pubmed-article:9870344 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:meshHeading | pubmed-meshheading:9870344-... | lld:pubmed |
| pubmed-article:9870344 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9870344 | pubmed:articleTitle | The non-competitive N-methyl-D-aspartate-antagonist memantine does not affect segmental mono- and polysynaptic reflexes in man. | lld:pubmed |
| pubmed-article:9870344 | pubmed:affiliation | Neurologische Klinik, Universität Tübingen, Germany. karsten.schepelmann@swol.de | lld:pubmed |
| pubmed-article:9870344 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9870344 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:9870344 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
