| pubmed-article:9845072 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C0027893 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C0009830 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:9845072 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:9845072 | pubmed:issue | 6709 | lld:pubmed |
| pubmed-article:9845072 | pubmed:dateCreated | 1998-12-11 | lld:pubmed |
| pubmed-article:9845072 | pubmed:abstractText | Genetic linkage analysis of rats that were selectively bred for alcohol preference identified a chromosomal region that includes the neuropeptide Y (NPY) gene. Alcohol-preferring rats have lower levels of NPY in several brain regions compared with alcohol-non-preferring rats. We therefore studied alcohol consumption by mice that completely lack NPY as a result of targeted gene disruption. Here we report that NPY-deficient mice show increased consumption, compared with wild-type mice, of solutions containing 6%, 10% and 20% (v/v) ethanol. NPY-deficient mice are also less sensitive to the sedative/hypnotic effects of ethanol, as shown by more rapid recovery from ethanol-induced sleep, even though plasma ethanol concentrations do not differ significantly from those of controls. In contrast, transgenic mice that overexpress a marked NPY gene in neurons that usually express it have a lower preference for ethanol and are more sensitive to the sedative/hypnotic effects of this drug than controls. These data are direct evidence that alcohol consumption and resistance are inversely related to NPY levels in the brain. | lld:pubmed |
| pubmed-article:9845072 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9845072 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9845072 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9845072 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9845072 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9845072 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9845072 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9845072 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9845072 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9845072 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:9845072 | pubmed:author | pubmed-author:MarshD JDJ | lld:pubmed |
| pubmed-article:9845072 | pubmed:author | pubmed-author:BernsteinI... | lld:pubmed |
| pubmed-article:9845072 | pubmed:author | pubmed-author:PalmiterR DRD | lld:pubmed |
| pubmed-article:9845072 | pubmed:author | pubmed-author:ThieleT ETE | lld:pubmed |
| pubmed-article:9845072 | pubmed:author | pubmed-author:Ste MarieLL | lld:pubmed |
| pubmed-article:9845072 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9845072 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:9845072 | pubmed:volume | 396 | lld:pubmed |
| pubmed-article:9845072 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9845072 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9845072 | pubmed:pagination | 366-9 | lld:pubmed |
| pubmed-article:9845072 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9845072 | pubmed:meshHeading | pubmed-meshheading:9845072-... | lld:pubmed |
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| pubmed-article:9845072 | pubmed:meshHeading | pubmed-meshheading:9845072-... | lld:pubmed |
| pubmed-article:9845072 | pubmed:meshHeading | pubmed-meshheading:9845072-... | lld:pubmed |
| pubmed-article:9845072 | pubmed:meshHeading | pubmed-meshheading:9845072-... | lld:pubmed |
| pubmed-article:9845072 | pubmed:meshHeading | pubmed-meshheading:9845072-... | lld:pubmed |
| pubmed-article:9845072 | pubmed:meshHeading | pubmed-meshheading:9845072-... | lld:pubmed |
| pubmed-article:9845072 | pubmed:meshHeading | pubmed-meshheading:9845072-... | lld:pubmed |
| pubmed-article:9845072 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9845072 | pubmed:articleTitle | Ethanol consumption and resistance are inversely related to neuropeptide Y levels. | lld:pubmed |
| pubmed-article:9845072 | pubmed:affiliation | Department of Psychology, University of Washington, Seattle 98195, USA. thiele@u.washington.edu | lld:pubmed |
| pubmed-article:9845072 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9845072 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9845072 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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