| pubmed-article:9838027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9838027 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:9838027 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:9838027 | lifeskim:mentions | umls-concept:C0021547 | lld:lifeskim |
| pubmed-article:9838027 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:9838027 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:9838027 | lifeskim:mentions | umls-concept:C0443264 | lld:lifeskim |
| pubmed-article:9838027 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9838027 | pubmed:dateCreated | 1999-1-27 | lld:pubmed |
| pubmed-article:9838027 | pubmed:abstractText | The three subtypes of inositol trisphosphate (InsP3) receptor expressed in mammalian cells are each capable of forming intracellular Ca2+ channels that are regulated by both InsP3 and cytosolic Ca2+. The InsP3 receptors of many, though perhaps not all, tissues are biphasically regulated by cytosolic Ca2+: a rapid stimulation of the receptors by modest increases in Ca2+ concentration is followed by a slower inhibition at higher Ca2+ concentrations. Despite the widespread occurrence of this form of regulation and the belief that it is an important element of the mechanisms responsible for the complex Ca2+ signals evoked by physiological stimuli, the underlying mechanisms are not understood. Both accessory proteins and Ca2+-binding sites on InsP3 receptors themselves have been proposed to mediate the effects of cytosolic Ca2+ on InsP3 receptor function, but the evidence is equivocal. The effects of cytosolic Ca2+ on InsP3 binding and channel opening, and the possible means whereby the effects are mediated are discussed in this review. | lld:pubmed |
| pubmed-article:9838027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9838027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9838027 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9838027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9838027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9838027 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9838027 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:9838027 | pubmed:author | pubmed-author:TaylorC WCW | lld:pubmed |
| pubmed-article:9838027 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9838027 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:9838027 | pubmed:volume | 1436 | lld:pubmed |
| pubmed-article:9838027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9838027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9838027 | pubmed:pagination | 19-33 | lld:pubmed |
| pubmed-article:9838027 | pubmed:dateRevised | 2007-7-18 | lld:pubmed |
| pubmed-article:9838027 | pubmed:meshHeading | pubmed-meshheading:9838027-... | lld:pubmed |
| pubmed-article:9838027 | pubmed:meshHeading | pubmed-meshheading:9838027-... | lld:pubmed |
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| pubmed-article:9838027 | pubmed:meshHeading | pubmed-meshheading:9838027-... | lld:pubmed |
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| pubmed-article:9838027 | pubmed:meshHeading | pubmed-meshheading:9838027-... | lld:pubmed |
| pubmed-article:9838027 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9838027 | pubmed:articleTitle | Inositol trisphosphate receptors: Ca2+-modulated intracellular Ca2+ channels. | lld:pubmed |
| pubmed-article:9838027 | pubmed:affiliation | Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK. cwt1000@cam.ac.uk | lld:pubmed |
| pubmed-article:9838027 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9838027 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:9838027 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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