| pubmed-article:9831295 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0003842 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C1660757 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:9831295 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:9831295 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9831295 | pubmed:dateCreated | 1999-2-8 | lld:pubmed |
| pubmed-article:9831295 | pubmed:abstractText | The role of endothelin-1 in vascular homeostasis is not yet clearly established. We investigated the responses to phenylephrine and acetylcholine in rat mesenteric resistance artery and aorta mounted in vitro in myographs after a 2-week treatment with endothelin-1 (5 pmol kg(-1) min(-1), n = 8). Systolic arterial blood pressure increased in endothelin-1-treated rats (171 +/- 7 mmHg vs. 196 +/- 6 mmHg, P < 0.05). In the aorta, chronic endothelin-1 significantly increased the dilator response to acetylcholine (maximal dilatation: 76 +/- 3 vs. 86 +/- 3% in control, P < 0.05). Acetylcholine-induced dilatation was decreased by nitric oxide (NO) synthase inhibition with NG-nitro-L-arginine methyl ester (L-NAME 100 micromol/l) and partly restored by cyclooxygenases inhibition (indomethacin, 10 micromol/l). In endothelin-1-treated rats, L-NAME-sensitive acetylcholine dilatation was lower than in the control, but dilator cyclooxygenase product(s) were found instead of constrictor cyclooxygenase product(s). In mesenteric resistance arteries chronic endothelin-1 increased the participation of cyclooxygenase products in acetylcholine-induced dilatation from 10 +/- 2 to 19 +/- 3%. In both types of arteries, phenylephrine-induced contraction was not affected by chronic endothelin-1. Thus chronic endothelin-1 increased the participation of dilator cyclooxygenase product(s) in acetylcholine-induced dilatation in the aorta and the mesenteric resistance arteries. | lld:pubmed |
| pubmed-article:9831295 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9831295 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9831295 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9831295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9831295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9831295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9831295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9831295 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9831295 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9831295 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9831295 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:9831295 | pubmed:author | pubmed-author:HenrionDD | lld:pubmed |
| pubmed-article:9831295 | pubmed:author | pubmed-author:TskeH JHJ | lld:pubmed |
| pubmed-article:9831295 | pubmed:author | pubmed-author:IglarzMM | lld:pubmed |
| pubmed-article:9831295 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9831295 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:9831295 | pubmed:volume | 359 | lld:pubmed |
| pubmed-article:9831295 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9831295 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9831295 | pubmed:pagination | 69-75 | lld:pubmed |
| pubmed-article:9831295 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9831295 | pubmed:meshHeading | pubmed-meshheading:9831295-... | lld:pubmed |
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| pubmed-article:9831295 | pubmed:meshHeading | pubmed-meshheading:9831295-... | lld:pubmed |
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| pubmed-article:9831295 | pubmed:meshHeading | pubmed-meshheading:9831295-... | lld:pubmed |
| pubmed-article:9831295 | pubmed:meshHeading | pubmed-meshheading:9831295-... | lld:pubmed |
| pubmed-article:9831295 | pubmed:meshHeading | pubmed-meshheading:9831295-... | lld:pubmed |
| pubmed-article:9831295 | pubmed:meshHeading | pubmed-meshheading:9831295-... | lld:pubmed |
| pubmed-article:9831295 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9831295 | pubmed:articleTitle | Chronic endothelin-1-induced changes in vascular reactivity in rat resistance arteries and aorta. | lld:pubmed |
| pubmed-article:9831295 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale U 141, IFR Circulation-Lariboisière, Université Paris VII, Hôpital Lariboisière, France. | lld:pubmed |
| pubmed-article:9831295 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9831295 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9831295 | lld:pubmed |
