| pubmed-article:9826705 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9826705 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:9826705 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:9826705 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9826705 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:9826705 | lifeskim:mentions | umls-concept:C0232981 | lld:lifeskim |
| pubmed-article:9826705 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:9826705 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:9826705 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:9826705 | pubmed:dateCreated | 1998-12-28 | lld:pubmed |
| pubmed-article:9826705 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826705 | pubmed:abstractText | The microrchidia, or morc, autosomal recessive mutation results in the arrest of spermatogenesis early in prophase I of meiosis. The morc mutation arose spontaneously during the development of a mouse strain transgenic for a tyrosinase cDNA construct. Morc -/- males are infertile and have grossly reduced testicular mass, whereas -/- females are normal, indicating that the Morc gene acts specifically during male gametogenesis. Immunofluorescence to synaptonemal complex antigens demonstrated that -/- male germ cells enter meiosis but fail to progress beyond zygotene or leptotene stage. An apoptosis assay revealed massive numbers of cells undergoing apoptosis in testes of -/- mice. No other abnormal phenotype was observed in mutant animals, with the exception of eye pigmentation caused by transgene expression in the retina. Spermatogenesis is normal in +/- males, despite significant transgene expression in germ cells. Genomic analysis of -/- animals indicates the presence of a deletion adjacent to the transgene. Identification of the gene inactivated by the transgene insertion may define a novel biochemical pathway involved in mammalian germ cell development and meiosis. | lld:pubmed |
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| pubmed-article:9826705 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9826705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9826705 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9826705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9826705 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9826705 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:HalabanRR | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:InoueNN | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:CobbJJ | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:WatsonM LML | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:HandelM AMA | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:MoreadithR... | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:ZinnA RAR | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:AlbrightG MGM | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:HessK DKD | lld:pubmed |
| pubmed-article:9826705 | pubmed:author | pubmed-author:DucheneC CCC | lld:pubmed |
| pubmed-article:9826705 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9826705 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:9826705 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9826705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9826705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9826705 | pubmed:pagination | 14361-6 | lld:pubmed |
| pubmed-article:9826705 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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