pubmed-article:9823451 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9823451 | lifeskim:mentions | umls-concept:C1511654 | lld:lifeskim |
pubmed-article:9823451 | lifeskim:mentions | umls-concept:C0005955 | lld:lifeskim |
pubmed-article:9823451 | lifeskim:mentions | umls-concept:C0222660 | lld:lifeskim |
pubmed-article:9823451 | lifeskim:mentions | umls-concept:C0029936 | lld:lifeskim |
pubmed-article:9823451 | lifeskim:mentions | umls-concept:C0815089 | lld:lifeskim |
pubmed-article:9823451 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:9823451 | pubmed:dateCreated | 1999-1-22 | lld:pubmed |
pubmed-article:9823451 | pubmed:abstractText | To clarify the relationship between the sequential changes of trabecular bone turnover and bone marrow cell development in ovariectomized (ovx) mice, bilateral tibiae of 8-week-old ddy mice were obtained. Histomorphometric analyses of the trabecular bone of the proximal tibia of ovx mice revealed increases in the bone formation rate and the osteoclast surface for the first 28 days postovariectomy. The trabecular bone volume showed a rapid decrease for the first 28 days and a steady state for the subsequent 14 days. In bone marrow cell culture experiments, the numbers of total and nonadherent bone marrow cells per tibia obtained from the ovx mice increased. The formation of osteogenic nodules and osteoclast-like multinucleated cells in the marrow cultures obtained from ovx limbs showed a significant increase on days 14 and 28 and returned to the sham-operated level by day 42. The numbers of colony forming units (fibroblastic) and colony forming units (granulocytes and macrophages) that developed from the marrow cells did not differ between the ovx and sham limbs at any time during the study period. Fluorescence-activated cell-sorter analysis revealed no population changes in the cell development of macrophages. These results demonstrate that there are two stages in the development of osteopenia after ovx. During the first 28 days after ovx, the ovariectomy enhances the developmental process from bone marrow stromal cells to osteoblasts and the terminal differentiation from osteoclast precursors to mature osteoclasts. The trabecular bone turnover also increases. In the subsequent 14 days, the changes in the osteogenic and osteoclastogenic potentials of the bone marrow cells are alleviated and the trabecular bone dynamics are in a steady state. The changes in bone marrow cell development are closely associated with those at the trabecular bone surface. | lld:pubmed |
pubmed-article:9823451 | pubmed:language | eng | lld:pubmed |
pubmed-article:9823451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9823451 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:9823451 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9823451 | pubmed:month | Nov | lld:pubmed |
pubmed-article:9823451 | pubmed:issn | 8756-3282 | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:NishidaSS | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:HiranoTT | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:SakaiAA | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:OkazakiYY | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:SudaTT | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:NorimuraTT | lld:pubmed |
pubmed-article:9823451 | pubmed:author | pubmed-author:OkimotoNN | lld:pubmed |
pubmed-article:9823451 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9823451 | pubmed:volume | 23 | lld:pubmed |
pubmed-article:9823451 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9823451 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9823451 | pubmed:pagination | 443-51 | lld:pubmed |
pubmed-article:9823451 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:9823451 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:9823451 | pubmed:articleTitle | Bone marrow cell development and trabecular bone dynamics after ovariectomy in ddy mice. | lld:pubmed |
pubmed-article:9823451 | pubmed:affiliation | Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan. a-sakai@med.uoeh-u.ac.jp | lld:pubmed |
pubmed-article:9823451 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9823451 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9823451 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9823451 | lld:pubmed |