| pubmed-article:9809069 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C1158537 | lld:lifeskim |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C1519877 | lld:lifeskim |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C0285266 | lld:lifeskim |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:9809069 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:9809069 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9809069 | pubmed:dateCreated | 1998-12-1 | lld:pubmed |
| pubmed-article:9809069 | pubmed:abstractText | Nonhomologous DNA end joining (NHEJ) is the major pathway for repairing double-strand DNA breaks. V(D)J recombination is a double-strand DNA breakage and rejoining process that relies on NHEJ for the joining steps. Here we show that the targeted disruption of both DNA ligase IV alleles in a human pre-B cell line renders the cells sensitive to ionizing radiation and ablates V(D)J recombination. This phenotype can only be reversed by complementation with DNA ligase IV but not by expression of either of the remaining two ligases, DNA ligase I or III. Hence, DNA ligase IV is the activity responsible for the ligation step in NHEJ and in V(D)J recombination. | lld:pubmed |
| pubmed-article:9809069 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9809069 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9809069 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9809069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9809069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9809069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9809069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9809069 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9809069 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9809069 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9809069 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:9809069 | pubmed:author | pubmed-author:ZimmerDD | lld:pubmed |
| pubmed-article:9809069 | pubmed:author | pubmed-author:SchwarzKK | lld:pubmed |
| pubmed-article:9809069 | pubmed:author | pubmed-author:LieberM RMR | lld:pubmed |
| pubmed-article:9809069 | pubmed:author | pubmed-author:GrawunderUU | lld:pubmed |
| pubmed-article:9809069 | pubmed:author | pubmed-author:FugmannSS | lld:pubmed |
| pubmed-article:9809069 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9809069 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:9809069 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9809069 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9809069 | pubmed:pagination | 477-84 | lld:pubmed |
| pubmed-article:9809069 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:meshHeading | pubmed-meshheading:9809069-... | lld:pubmed |
| pubmed-article:9809069 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9809069 | pubmed:articleTitle | DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes. | lld:pubmed |
| pubmed-article:9809069 | pubmed:affiliation | University of Southern California School of Medicine, Norris Comprehensive Cancer Center, Department of Pathology, Los Angeles 90033, USA. | lld:pubmed |
| pubmed-article:9809069 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9809069 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9809069 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3978 | entrezgene:pubmed | pubmed-article:9809069 | lld:entrezgene |
| entrez-gene:3980 | entrezgene:pubmed | pubmed-article:9809069 | lld:entrezgene |
| entrez-gene:3981 | entrezgene:pubmed | pubmed-article:9809069 | lld:entrezgene |
| entrez-gene:7518 | entrezgene:pubmed | pubmed-article:9809069 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9809069 | lld:pubmed |
