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pubmed-article:9808182pubmed:abstractTextNegative as well as positive co-stimulation appears to play an important role in controlling T cell activation. CTLA-4 has been proposed to negatively regulate T cell responses. CTLA-4-deficient mice develop a lymphoproliferative disorder, initiated by the activation and expansion of CD4+ T cells. To assess the function of CTLA-4 on CD8+ T cells, CTLA-4(-/-) animals were crossed to an MHC class I-restricted 2C TCR transgenic mouse line. We demonstrate that although the primary T cell responses were similar, the CTLA-4-deficient 2C TCR+ CD8+ T cells displayed a greater proliferative response upon secondary stimulation than the 2C TCR+ CD8+ T cells from CTLA-4 wild-type mice. These results suggest that CTLA-4 regulates antigen-specific memory CD8+ T cell responses.lld:pubmed
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pubmed-article:9808182pubmed:articleTitleSecondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells.lld:pubmed
pubmed-article:9808182pubmed:affiliationHoward Hughes Medical Research Institute, Department of Molecular and Cellular Biology, University of California, Berkeley 94720, USA.lld:pubmed
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