pubmed-article:9808182 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C0175668 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
pubmed-article:9808182 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
pubmed-article:9808182 | pubmed:issue | 10 | lld:pubmed |
pubmed-article:9808182 | pubmed:dateCreated | 1998-12-15 | lld:pubmed |
pubmed-article:9808182 | pubmed:abstractText | Negative as well as positive co-stimulation appears to play an important role in controlling T cell activation. CTLA-4 has been proposed to negatively regulate T cell responses. CTLA-4-deficient mice develop a lymphoproliferative disorder, initiated by the activation and expansion of CD4+ T cells. To assess the function of CTLA-4 on CD8+ T cells, CTLA-4(-/-) animals were crossed to an MHC class I-restricted 2C TCR transgenic mouse line. We demonstrate that although the primary T cell responses were similar, the CTLA-4-deficient 2C TCR+ CD8+ T cells displayed a greater proliferative response upon secondary stimulation than the 2C TCR+ CD8+ T cells from CTLA-4 wild-type mice. These results suggest that CTLA-4 regulates antigen-specific memory CD8+ T cell responses. | lld:pubmed |
pubmed-article:9808182 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9808182 | pubmed:language | eng | lld:pubmed |
pubmed-article:9808182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9808182 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:9808182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:9808182 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:9808182 | pubmed:month | Oct | lld:pubmed |
pubmed-article:9808182 | pubmed:issn | 0014-2980 | lld:pubmed |
pubmed-article:9808182 | pubmed:author | pubmed-author:SullivanT JTJ | lld:pubmed |
pubmed-article:9808182 | pubmed:author | pubmed-author:AllisonJ PJP | lld:pubmed |
pubmed-article:9808182 | pubmed:author | pubmed-author:ChambersC ACA | lld:pubmed |
pubmed-article:9808182 | pubmed:author | pubmed-author:TruongTT | lld:pubmed |
pubmed-article:9808182 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:9808182 | pubmed:volume | 28 | lld:pubmed |
pubmed-article:9808182 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:9808182 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:9808182 | pubmed:pagination | 3137-43 | lld:pubmed |
pubmed-article:9808182 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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pubmed-article:9808182 | pubmed:year | 1998 | lld:pubmed |
pubmed-article:9808182 | pubmed:articleTitle | Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells. | lld:pubmed |
pubmed-article:9808182 | pubmed:affiliation | Howard Hughes Medical Research Institute, Department of Molecular and Cellular Biology, University of California, Berkeley 94720, USA. | lld:pubmed |
pubmed-article:9808182 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:9808182 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:9808182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:12477 | entrezgene:pubmed | pubmed-article:9808182 | lld:entrezgene |
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