| pubmed-article:9806633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C1335376 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9806633 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9806633 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9806633 | pubmed:dateCreated | 1998-11-18 | lld:pubmed |
| pubmed-article:9806633 | pubmed:abstractText | Physiologically, TCR signaling is unlikely to result from the cross-linking of TCR-CD3 complexes, given the low density of specific peptide-MHC complexes on antigen-presenting cells. We therefore have tested directly an alternative model for antigen recognition. We show that monomers of soluble peptide-MHC trigger Ca2+ responses in CD8alphabeta+ T cells. This response is not observed in CD8- T cells and when either the CD8:MHC or CD8:Lck interactions are prevented. This demonstrates that an intact CD8 coreceptor is necessary for effective TCR signaling in response to monomeric peptide-MHC molecules. We propose that this heterodimerization of TCR and CD8 by peptide-MHC corresponds to the physiological event normally involved during antigen-specific signal transduction. | lld:pubmed |
| pubmed-article:9806633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9806633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9806633 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9806633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9806633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9806633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9806633 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9806633 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:TrautmannAA | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:GrégoireCC | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:KourilskyPP | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:MalissenBB | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:DarcheSS | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:AbastadoJ PJP | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:DelonJJ | lld:pubmed |
| pubmed-article:9806633 | pubmed:author | pubmed-author:LemaîtreFF | lld:pubmed |
| pubmed-article:9806633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9806633 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:9806633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9806633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9806633 | pubmed:pagination | 467-73 | lld:pubmed |
| pubmed-article:9806633 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:9806633 | pubmed:meshHeading | pubmed-meshheading:9806633-... | lld:pubmed |
| pubmed-article:9806633 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9806633 | pubmed:articleTitle | CD8 expression allows T cell signaling by monomeric peptide-MHC complexes. | lld:pubmed |
| pubmed-article:9806633 | pubmed:affiliation | Laboratoire d'Immunologie Cellulaire UMR CNRS 7627 CERVI, Paris, France. | lld:pubmed |
| pubmed-article:9806633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9806633 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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