| pubmed-article:9802926 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C0439801 | lld:lifeskim |
| pubmed-article:9802926 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:9802926 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9802926 | pubmed:dateCreated | 1999-1-25 | lld:pubmed |
| pubmed-article:9802926 | pubmed:abstractText | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of large amounts of characteristic autoantibodies. Anti-Sm and anti-nRNP (also known as anti-spliceosome) autoantibodies are among these. Previous epitope mapping of anti-spliceosomal antibodies has identified multiple antigenic determinants within this complex immune response. In this report we describe an SLE patient with a relatively simple, long-lasting anti-spliceosomal response. In the earliest serum sample tested the autoimmune response appeared restricted to the similar peptides PPPGMR(P,G)P of Sm B/B', PAPGMRPP of nRNP C, and PPPGMIPP of nRNP A. Unlike all the other tested lupus patients with anti-spliceosomal autoantibodies, in this patient these proline-rich epitopes remained the primary target for humoral autoimmunity in subsequent serum samples collected over many years. Absorption of anti-PAPGMRPP antibodies also removed binding to PPPGMR(P,G)P and PPPGMIPP. Isolated antibodies to PAPGMRPP were capable of binding Sm B/B', nRNP C and nRNP A by Western blot. For this particular SLE patient the autoimmune response observed against these three proteins is a single cross-reactive response against a similar proline-rich motif. Also, this patient has failed to undergo the B cell epitope spreading, typically observed in the naturally arising autoimmune response against the spliceosome in human lupus patients. | lld:pubmed |
| pubmed-article:9802926 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9802926 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9802926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9802926 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9802926 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9802926 | pubmed:issn | 0896-8411 | lld:pubmed |
| pubmed-article:9802926 | pubmed:author | pubmed-author:JamesJ AJA | lld:pubmed |
| pubmed-article:9802926 | pubmed:author | pubmed-author:HarleyJ BJB | lld:pubmed |
| pubmed-article:9802926 | pubmed:author | pubmed-author:SchillingA... | lld:pubmed |
| pubmed-article:9802926 | pubmed:author | pubmed-author:ArbuckleM RMR | lld:pubmed |
| pubmed-article:9802926 | pubmed:copyrightInfo | Copyright 1998 Academic Press. | lld:pubmed |
| pubmed-article:9802926 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9802926 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:9802926 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9802926 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9802926 | pubmed:pagination | 431-8 | lld:pubmed |
| pubmed-article:9802926 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
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| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
| pubmed-article:9802926 | pubmed:meshHeading | pubmed-meshheading:9802926-... | lld:pubmed |
| pubmed-article:9802926 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9802926 | pubmed:articleTitle | A limited lupus anti-spliceosomal response targets a cross-reactive, proline-rich motif. | lld:pubmed |
| pubmed-article:9802926 | pubmed:affiliation | Arthritis and Immunology Program, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA. | lld:pubmed |
| pubmed-article:9802926 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9802926 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9802926 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9802926 | pubmed:publicationType | Case Reports | lld:pubmed |
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