| pubmed-article:9801815 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9801815 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:9801815 | lifeskim:mentions | umls-concept:C0178576 | lld:lifeskim |
| pubmed-article:9801815 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:9801815 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:9801815 | lifeskim:mentions | umls-concept:C1709743 | lld:lifeskim |
| pubmed-article:9801815 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:9801815 | pubmed:dateCreated | 1999-1-12 | lld:pubmed |
| pubmed-article:9801815 | pubmed:abstractText | Covalent crosslinks can control local peptide conformation. In tripeptide sequences of the general formula Cys-Xxx-Cys, cysteine disulfides have been previously shown to enforce a C7 equatorial gamma-turn conformation (also referred to as an inverse gamma-turn). Much less is known about the effects of dityrosine and ditryptophan crosslinks on local peptide structure. In a series of tripeptides, ditryptophan crosslinks were formed using the two-step process of acid-promoted Mannich dimerization followed by oxidative aromatization. In these peptides, with the general formula Trp-Xxx-Trp (Xxx not equal to Gly), ditryptophan crosslinks were found to stabilize a C7 equatorial gamma-turn conformation in DMSO-d6. Rigorous support for a C7 equatorial conformation in the crosslinked sequence Trp-Pro-Trp came from a variety of 1H NMR experiments and molecular modelling. Interproton distances were derived from NOE buildups that were determined through a series of double pulsed field gradient spin echo (DPFGSE) experiments. In addition, the small temperature dependence of the i+2 NH chemical shifts (delta delta/delta T < 2 ppm/degree C) provided further support for the intramolecular hydrogen bond which defines a gamma-turn. | lld:pubmed |
| pubmed-article:9801815 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9801815 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9801815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9801815 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9801815 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9801815 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:9801815 | pubmed:author | pubmed-author:LamY KYK | lld:pubmed |
| pubmed-article:9801815 | pubmed:author | pubmed-author:IZTT | lld:pubmed |
| pubmed-article:9801815 | pubmed:author | pubmed-author:ShakaA JAJ | lld:pubmed |
| pubmed-article:9801815 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:9801815 | pubmed:author | pubmed-author:StachelS JSJ | lld:pubmed |
| pubmed-article:9801815 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9801815 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:9801815 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9801815 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9801815 | pubmed:pagination | 1439-46 | lld:pubmed |
| pubmed-article:9801815 | pubmed:dateRevised | 2011-1-24 | lld:pubmed |
| pubmed-article:9801815 | pubmed:meshHeading | pubmed-meshheading:9801815-... | lld:pubmed |
| pubmed-article:9801815 | pubmed:meshHeading | pubmed-meshheading:9801815-... | lld:pubmed |
| pubmed-article:9801815 | pubmed:meshHeading | pubmed-meshheading:9801815-... | lld:pubmed |
| pubmed-article:9801815 | pubmed:meshHeading | pubmed-meshheading:9801815-... | lld:pubmed |
| pubmed-article:9801815 | pubmed:meshHeading | pubmed-meshheading:9801815-... | lld:pubmed |
| pubmed-article:9801815 | pubmed:meshHeading | pubmed-meshheading:9801815-... | lld:pubmed |
| pubmed-article:9801815 | pubmed:meshHeading | pubmed-meshheading:9801815-... | lld:pubmed |
| pubmed-article:9801815 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9801815 | pubmed:articleTitle | Stabilization of a C7 equatorial gamma turn in DMSO-d6 by a ditryptophan crosslink. | lld:pubmed |
| pubmed-article:9801815 | pubmed:affiliation | Department of Chemistry, University of California-Irvine 92697-2025, USA. | lld:pubmed |
| pubmed-article:9801815 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9801815 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9801815 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9801815 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
