| pubmed-article:9751276 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9751276 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:9751276 | lifeskim:mentions | umls-concept:C0596577 | lld:lifeskim |
| pubmed-article:9751276 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:9751276 | lifeskim:mentions | umls-concept:C0720298 | lld:lifeskim |
| pubmed-article:9751276 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:9751276 | pubmed:dateCreated | 1998-10-1 | lld:pubmed |
| pubmed-article:9751276 | pubmed:abstractText | The interaction between the estrogen receptor and a variety of flavonoids was studied in the presence or absence of estradiol using a stably-transfected human breast cancer cell line (MVLN). On the other hand, flavonoids were evaluated for their effects on proliferation in estrogen-dependent (MCF-7) and independent (MDA-MB231) human breast cancer cells. We established a relationship structure-activity and determined regions and/or substituents essential for estrogenic or antiestrogenic activities. In contrast, we did not find the same relationship for cell proliferation. Among all flavonoids used, only 7-methoxyflavanone and 7,8-dihydroxyflavone at high concentrations (50 microM) possess antiestrogenic and antiproliferative activities. These results suggest that two hydroxyls (in positions 7 and 8) or 7-methoxy substituents are essential for the antiestrogenic activity of flavonoids. However, it seems that flavonoids at high concentrations exert their antiproliferative activity through other estrogen receptor-independent mechanisms. | lld:pubmed |
| pubmed-article:9751276 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9751276 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9751276 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9751276 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9751276 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:9751276 | pubmed:author | pubmed-author:NicolasJ CJC | lld:pubmed |
| pubmed-article:9751276 | pubmed:author | pubmed-author:HabriouxGG | lld:pubmed |
| pubmed-article:9751276 | pubmed:author | pubmed-author:VarnaiSS | lld:pubmed |
| pubmed-article:9751276 | pubmed:author | pubmed-author:Le BailJ CJC | lld:pubmed |
| pubmed-article:9751276 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9751276 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:9751276 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:9751276 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9751276 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9751276 | pubmed:pagination | 209-16 | lld:pubmed |
| pubmed-article:9751276 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9751276 | pubmed:meshHeading | pubmed-meshheading:9751276-... | lld:pubmed |
| pubmed-article:9751276 | pubmed:meshHeading | pubmed-meshheading:9751276-... | lld:pubmed |
| pubmed-article:9751276 | pubmed:meshHeading | pubmed-meshheading:9751276-... | lld:pubmed |
| pubmed-article:9751276 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9751276 | pubmed:articleTitle | Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. | lld:pubmed |
| pubmed-article:9751276 | pubmed:affiliation | UPRES EA 1085, Laboratoire de Biochimie, Faculté de Pharmacie, Limoges, France. | lld:pubmed |
| pubmed-article:9751276 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9751276 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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