| pubmed-article:9750167 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9750167 | lifeskim:mentions | umls-concept:C0017037 | lld:lifeskim |
| pubmed-article:9750167 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:9750167 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9750167 | lifeskim:mentions | umls-concept:C1157234 | lld:lifeskim |
| pubmed-article:9750167 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9750167 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9750167 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9750167 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9750167 | pubmed:dateCreated | 1998-10-30 | lld:pubmed |
| pubmed-article:9750167 | pubmed:abstractText | The nitric oxide (NO) donors S-nitrosopenicillamine or DetaNONOate, which release NO at a rate of 0-15 nM sec-1, were exposed to rat aortic vascular smooth muscle cells for a period of 0-24 h. This treatment resulted in an increase in total glutathione levels of two- to threefold under conditions where no cytotoxicity was detected. The signaling pathways do not involve activation of protein kinase G Ialpha nor are they cGMP dependent. Oxidation of reduced glutathione (GSH) was found after exposure to NO for 3-4 h at rates of formation at or above 8 nM sec-1. Increased intracellular GSH was due to enhanced expression of the rate-limiting enzyme for GSH synthesis, gamma-glutamylcysteine synthetase. Since NO has been shown previously to protect cells against oxidative stress, we propose that the increase in GSH by NO is a potential mechanism for enhancing the antioxidant defenses of the cell. This result also has important implications for identifying redox-sensitive cell signaling pathways that can be activated by NO. | lld:pubmed |
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| pubmed-article:9750167 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9750167 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9750167 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9750167 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9750167 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9750167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9750167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9750167 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9750167 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9750167 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9750167 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:PatelR PRP | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:FormanH JHJ | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:LincolnTT | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:CaoXX | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:Darley-UsmarV... | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:MessinaJ LJL | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:LIPP | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:McAndrewJJ | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:CornwellTT | lld:pubmed |
| pubmed-article:9750167 | pubmed:author | pubmed-author:MoelleringDD | lld:pubmed |
| pubmed-article:9750167 | pubmed:copyrightInfo | Copyright 1998 Academic Press. | lld:pubmed |
| pubmed-article:9750167 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9750167 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9750167 | pubmed:volume | 358 | lld:pubmed |
| pubmed-article:9750167 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9750167 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9750167 | pubmed:pagination | 74-82 | lld:pubmed |
| pubmed-article:9750167 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
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| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:meshHeading | pubmed-meshheading:9750167-... | lld:pubmed |
| pubmed-article:9750167 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9750167 | pubmed:articleTitle | Nitric oxide-dependent induction of glutathione synthesis through increased expression of gamma-glutamylcysteine synthetase. | lld:pubmed |
| pubmed-article:9750167 | pubmed:affiliation | Molecular and Cellular Division, Center for Free Radical Biology, University of Alabama at Birmingham, Volker Hall Room GO38, 1670 University Boulevard, Birmingham, Alabama, 35294-0019, USA. | lld:pubmed |
| pubmed-article:9750167 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9750167 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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