| pubmed-article:9736643 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9736643 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9736643 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:9736643 | lifeskim:mentions | umls-concept:C0026973 | lld:lifeskim |
| pubmed-article:9736643 | lifeskim:mentions | umls-concept:C0027740 | lld:lifeskim |
| pubmed-article:9736643 | lifeskim:mentions | umls-concept:C0032824 | lld:lifeskim |
| pubmed-article:9736643 | lifeskim:mentions | umls-concept:C1416543 | lld:lifeskim |
| pubmed-article:9736643 | lifeskim:mentions | umls-concept:C0260043 | lld:lifeskim |
| pubmed-article:9736643 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:9736643 | pubmed:dateCreated | 1998-10-2 | lld:pubmed |
| pubmed-article:9736643 | pubmed:abstractText | In mammalian myelinated nerves, the internodal axon that is normally concealed by the myelin sheath expresses a rich repertoire of K channel subtypes thought to be important in modulating action potential propagation. The function of myelin-covered K channels at transition zones, however, has remained unexplored. Here we show that deleting the voltage-sensitive potassium channel Kv1.1 from mice confers a marked temperature-sensitivity to neuromuscular transmission in postnatal day 14 (P14)-P21 mice. Using immunofluorescence and electrophysiology, we examined contributions of four regions of the peripheral nervous system to the mutant phenotype: the nerve trunk, the myelinated segment preceding the terminal, the presynaptic terminal membrane itself, and the muscle. We conclude that the temperature-sensitive neuromuscular transmission is accounted for solely by a deficiency in Kv1.1 normally concealed in the myelinated segments just preceding the terminal. This paper demonstrates that under certain situations of physiological stress, the functional role of myelin-covered K channels is dramatically enhanced as the transition zone at the neuromuscular junction is approached. | lld:pubmed |
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| pubmed-article:9736643 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9736643 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9736643 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9736643 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9736643 | pubmed:issn | 0270-6474 | lld:pubmed |
| pubmed-article:9736643 | pubmed:author | pubmed-author:ChiuS YSY | lld:pubmed |
| pubmed-article:9736643 | pubmed:author | pubmed-author:MessinaOO | lld:pubmed |
| pubmed-article:9736643 | pubmed:author | pubmed-author:ZhouLL | lld:pubmed |
| pubmed-article:9736643 | pubmed:author | pubmed-author:ZhangC LCL | lld:pubmed |
| pubmed-article:9736643 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9736643 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9736643 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9736643 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9736643 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9736643 | pubmed:pagination | 7200-15 | lld:pubmed |
| pubmed-article:9736643 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9736643 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9736643 | pubmed:articleTitle | Temperature-sensitive neuromuscular transmission in Kv1.1 null mice: role of potassium channels under the myelin sheath in young nerves. | lld:pubmed |
| pubmed-article:9736643 | pubmed:affiliation | Department of Physiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA. | lld:pubmed |
| pubmed-article:9736643 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9736643 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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