| pubmed-article:9716027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C0208804 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C1514475 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C0918012 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:9716027 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:9716027 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9716027 | pubmed:dateCreated | 1998-9-4 | lld:pubmed |
| pubmed-article:9716027 | pubmed:abstractText | The proliferative activity of a tumour is considered to be an important prognostic factor in primary breast cancer. We have investigated the prognostic value of the MIB-1 labelling index in 341 patients with primary breast cancer and compared the results with the S-phase fraction in 220 patients of the same cohort. All patients were treated in one hospital and had a median follow-up of 128 months. No correlation between MIB-1 labelling and S-phase fraction could be demonstrated. MIB-1 had prognostic value for disease-free survival in the whole group of patients (P < 0.001) and in the node-negative subgroup (P < 0.001). In multivariate analysis, MIB-1 was an independent prognostic factor (P = 0.004) besides axillary lymph node status (P = 0.001). In univariate analysis high S-phase fraction was associated with decreased overall survival (P = 0.04); however, not in multivariate analysis. Moreover, S-phase fraction had a borderline prognostic significance for post-relapse survival in multivariate analysis (P= 0.08). Thus, in conclusion, the growth fraction of a tumour as determined by the MIB-1 labelling index is an important prognostic factor in patients with primary breast cancer. | lld:pubmed |
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| pubmed-article:9716027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9716027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9716027 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9716027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9716027 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9716027 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:9716027 | pubmed:author | pubmed-author:HillenH FHF | lld:pubmed |
| pubmed-article:9716027 | pubmed:author | pubmed-author:HupperetsP... | lld:pubmed |
| pubmed-article:9716027 | pubmed:author | pubmed-author:JansenR LRL | lld:pubmed |
| pubmed-article:9716027 | pubmed:author | pubmed-author:ArendsJ WJW | lld:pubmed |
| pubmed-article:9716027 | pubmed:author | pubmed-author:VolovicsAA | lld:pubmed |
| pubmed-article:9716027 | pubmed:author | pubmed-author:SchoutenH CHC | lld:pubmed |
| pubmed-article:9716027 | pubmed:author | pubmed-author:Joosten-Achja... | lld:pubmed |
| pubmed-article:9716027 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9716027 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:9716027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9716027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9716027 | pubmed:pagination | 460-5 | lld:pubmed |
| pubmed-article:9716027 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9716027 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9716027 | pubmed:articleTitle | MIB-1 labelling index is an independent prognostic marker in primary breast cancer. | lld:pubmed |
| pubmed-article:9716027 | pubmed:affiliation | Department of Internal Medicine, University Hospital Maastricht, The Netherlands. | lld:pubmed |
| pubmed-article:9716027 | pubmed:publicationType | Journal Article | lld:pubmed |
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