| pubmed-article:9697772 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C0965644 | lld:lifeskim |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C1333897 | lld:lifeskim |
| pubmed-article:9697772 | lifeskim:mentions | umls-concept:C1704838 | lld:lifeskim |
| pubmed-article:9697772 | pubmed:issue | 6692 | lld:pubmed |
| pubmed-article:9697772 | pubmed:dateCreated | 1998-8-13 | lld:pubmed |
| pubmed-article:9697772 | pubmed:abstractText | As a result of deprivation of oxygen (hypoxia) and nutrients, the growth and viability of cells is reduced. Hypoxia-inducible factor (HIF)-1alpha helps to restore oxygen homeostasis by inducing glycolysis, erythropoiesis and angiogenesis. Here we show that hypoxia and hypoglycaemia reduce proliferation and increase apoptosis in wild-type (HIF-1alpha+/+) embryonic stem (ES) cells, but not in ES cells with inactivated HIF-1alpha genes (HIF-1alpha-/-); however, a deficiency of HIF-1alpha does not affect apoptosis induced by cytokines. We find that hypoxia/hypoglycaemia-regulated genes involved in controlling the cell cycle are either HIF-1alpha-dependent (those encoding the proteins p53, p21, Bcl-2) or HIF-1alpha-independent (p27, GADD153), suggesting that there are at least two different adaptive responses to being deprived of oxygen and nutrients. Loss of HIF-1alpha reduces hypoxia-induced expression of vascular endothelial growth factor, prevents formation of large vessels in ES-derived tumours, and impairs vascular function, resulting in hypoxic microenvironments within the tumour mass. However, growth of HIF-1alpha tumours was not retarded but was accelerated, owing to decreased hypoxia-induced apoptosis and increased stress-induced proliferation. As hypoxic stress contributes to many (patho)biological disorders, this new role for HIF-1alpha in hypoxic control of cell growth and death may be of general pathophysiological importance. | lld:pubmed |
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| pubmed-article:9697772 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9697772 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9697772 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9697772 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9697772 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9697772 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:CollenDD | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:HULLR WRW | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:JainR KRK | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:AbramovitchRR | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:BonoFF | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:MoontMM | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:NeemanMM | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:DewerchinMM | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:FukumuraDD | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:HerbertJ MJM | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:RatcliffePP | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:MaxwellPP | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:CarmelietPP | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:DowRR | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:KeshenTT | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:BrusselmansKK | lld:pubmed |
| pubmed-article:9697772 | pubmed:author | pubmed-author:KeshertEE | lld:pubmed |
| pubmed-article:9697772 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9697772 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:9697772 | pubmed:volume | 394 | lld:pubmed |
| pubmed-article:9697772 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9697772 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9697772 | pubmed:pagination | 485-90 | lld:pubmed |
| pubmed-article:9697772 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
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| pubmed-article:9697772 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9697772 | pubmed:articleTitle | Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. | lld:pubmed |
| pubmed-article:9697772 | pubmed:affiliation | Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium. Peter.Carmeliet@med.kuleuven.ac.be | lld:pubmed |
| pubmed-article:9697772 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9697772 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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