| pubmed-article:9683818 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C0027215 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C0042172 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C2239176 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C1564904 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9683818 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9683818 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9683818 | pubmed:dateCreated | 1998-9-21 | lld:pubmed |
| pubmed-article:9683818 | pubmed:abstractText | Cadherins are Ca2+-dependent cell-cell adhesion molecules, and are involved in the formation and maintenance of the histo-architecture. Using a combination of biochemical and immunohistochemical methods, we analyzed the expression of the cadherin-catenin complex in 34 human hepatocellular carcinomas. Unexpectedly, we found the expression of N (neural)-cadherin in normal hepatocytes and all hepatocellular carcinomas examined. In 18 cases, the decreased expression of E (epithelial)-cadherin was observed. Among them, the decreased expression of alpha-catenin and gamma-catenin (plakoglobin) was also observed in 9 and 6 cases, respectively. Thus the decreased expression of alpha-catenin and gamma-catenin was apparently preceded by the decreased expression of E-cadherin. The decreased expression of beta-catenin was not observed in any of the cases analyzed. beta-Catenin was found to accumulate in the cytoplasm of hepatocellular carcinomas with the decreased expression of E-cadherin, despite the presence of N-cadherin at the cell-cell contacts. These results suggest a pivotal role of E-cadherin in the intracellular distribution of catenins in hepatocellular carcinomas. | lld:pubmed |
| pubmed-article:9683818 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9683818 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9683818 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9683818 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9683818 | pubmed:issn | 1021-335X | lld:pubmed |
| pubmed-article:9683818 | pubmed:author | pubmed-author:OzawaMM | lld:pubmed |
| pubmed-article:9683818 | pubmed:author | pubmed-author:UenoSS | lld:pubmed |
| pubmed-article:9683818 | pubmed:author | pubmed-author:TanabeGG | lld:pubmed |
| pubmed-article:9683818 | pubmed:author | pubmed-author:NurukiKK | lld:pubmed |
| pubmed-article:9683818 | pubmed:author | pubmed-author:HamanoueMM | lld:pubmed |
| pubmed-article:9683818 | pubmed:author | pubmed-author:AikouTT | lld:pubmed |
| pubmed-article:9683818 | pubmed:author | pubmed-author:ToyoyamaHH | lld:pubmed |
| pubmed-article:9683818 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9683818 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:9683818 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9683818 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9683818 | pubmed:pagination | 1109-14 | lld:pubmed |
| pubmed-article:9683818 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9683818 | pubmed:meshHeading | pubmed-meshheading:9683818-... | lld:pubmed |
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| pubmed-article:9683818 | pubmed:meshHeading | pubmed-meshheading:9683818-... | lld:pubmed |
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| pubmed-article:9683818 | pubmed:meshHeading | pubmed-meshheading:9683818-... | lld:pubmed |
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| pubmed-article:9683818 | pubmed:meshHeading | pubmed-meshheading:9683818-... | lld:pubmed |
| pubmed-article:9683818 | pubmed:articleTitle | E-cadherin but not N-cadherin expression is correlated with the intracellular distribution of catenins in human hepatocellular carcinomas. | lld:pubmed |
| pubmed-article:9683818 | pubmed:affiliation | Departments of Biochemistry and Surgery, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan. | lld:pubmed |
| pubmed-article:9683818 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9683818 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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