| pubmed-article:9679056 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9679056 | lifeskim:mentions | umls-concept:C1333336 | lld:lifeskim |
| pubmed-article:9679056 | lifeskim:mentions | umls-concept:C1571580 | lld:lifeskim |
| pubmed-article:9679056 | lifeskim:mentions | umls-concept:C0392337 | lld:lifeskim |
| pubmed-article:9679056 | lifeskim:mentions | umls-concept:C0301039 | lld:lifeskim |
| pubmed-article:9679056 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:9679056 | pubmed:dateCreated | 1998-8-21 | lld:pubmed |
| pubmed-article:9679056 | pubmed:abstractText | TGF-beta and activin induce the phosphorylation and activation of Smad2 and Smad3, but how these proteins stimulate gene transcription is poorly understood. We report that TGF-beta receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its oligomerization partner Smad4 is negatively regulated by Smad-intramolecular interactions. Furthermore, p300 and TGF-beta receptor-phosphorylated Smad3 synergistically augment transcriptional activation. Thus, CBP/p300 are important components of activin/TGF-beta signaling and may mediate the antioncogenic functions of Smad2 and Smad4. | lld:pubmed |
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| pubmed-article:9679056 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9679056 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9679056 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9679056 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:9679056 | pubmed:author | pubmed-author:HunterTT | lld:pubmed |
| pubmed-article:9679056 | pubmed:author | pubmed-author:JanknechtRR | lld:pubmed |
| pubmed-article:9679056 | pubmed:author | pubmed-author:WellsN JNJ | lld:pubmed |
| pubmed-article:9679056 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9679056 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9679056 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:9679056 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9679056 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9679056 | pubmed:pagination | 2114-9 | lld:pubmed |
| pubmed-article:9679056 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9679056 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9679056 | pubmed:articleTitle | TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. | lld:pubmed |
| pubmed-article:9679056 | pubmed:affiliation | Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037 USA. rjanknecht@aim.salk.edu | lld:pubmed |
| pubmed-article:9679056 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9679056 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9679056 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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