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pubmed-article:9675096pubmed:abstractTextTo investigate the molecular mechanism of the melatonin rhythm in the mammalian retina, we examined the temporal mRNA expression pattern of arylalkylamine (serotonin) N-acetyltransferase (AA-NAT), the rate-limiting enzyme in melatonin synthesis in the rat retina. Rat AA-NAT mRNA was detected exclusively in the retinal photoreceptors in the outer nuclear layer--low during the day and increased more than threefold at night. The nocturnal AA-NAT expression in rat retina was also confirmed by RNase protection and the AA-NAT enzymatic activity. This is the first report to localize the site of AA-NAT mRNA circadian expression in mammalian photoreceptor cells.lld:pubmed
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pubmed-article:9675096pubmed:pagination115-20lld:pubmed
pubmed-article:9675096pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:9675096pubmed:articleTitleThe localization of the site of arylalkylamine N-acetyltransferase circadian expression in the photoreceptor cells of mammalian retina.lld:pubmed
pubmed-article:9675096pubmed:affiliationNational Institute of Bioscience and Human Technology, Agency of Industrial Science and Technology, MITI, Ibaraki, Japan.lld:pubmed
pubmed-article:9675096pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9675096pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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