| pubmed-article:9654113 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9654113 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:9654113 | lifeskim:mentions | umls-concept:C0079083 | lld:lifeskim |
| pubmed-article:9654113 | lifeskim:mentions | umls-concept:C0079490 | lld:lifeskim |
| pubmed-article:9654113 | lifeskim:mentions | umls-concept:C0040223 | lld:lifeskim |
| pubmed-article:9654113 | lifeskim:mentions | umls-concept:C0011546 | lld:lifeskim |
| pubmed-article:9654113 | lifeskim:mentions | umls-concept:C1334117 | lld:lifeskim |
| pubmed-article:9654113 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:9654113 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:9654113 | pubmed:dateCreated | 1998-7-9 | lld:pubmed |
| pubmed-article:9654113 | pubmed:abstractText | A growing body of data suggests that cancer therapy may be improved and toxicity reduced by administration of antineoplastic agents and cytokines at carefully selected times of the day. The time-dependent effects of each of the drugs have been documented, but not their mutual time dependencies. In the present studies we sought to determine the best time for granulocyte colony-stimulating factor (G-CSF) administration after carboplatin treatment. Carboplatin was injected in different groups of ICR mice at four different circadian stages for 5 consecutive days. Mice were synchronized with an alternation of 12 h of light (from 6:00 a.m. to 6:00 p.m.) and 12 h of darkness. After the last injection, peripheral WBCs of three mice from each group were counted every 4 h over a 24-h period. Bone marrow toxicity was estimated with the mean 24-h WBC count. The most severe leukopenia occurred in the group injected at 3:00 p.m. - 9 h after light onset. The second set of experiments evaluated the time-dependent effect of G-CSF when singly injected or given after carboplatin injections for 5 days only at 3:00 p.m. G-CSF was injected into various groups on days 8 and 9 at the same four different circadian stages. On the 10th day after the first injection, peripheral WBCs of three mice from each group were counted every 4 h over a 24-h period. Time-dependent effects were observed when G-CSF was injected as a single agent. When G-CSF was given at various times to the group with the most severe carboplatin-induced leukopenia, peripheral WBC count recovery was monitored at all injection times; it reached its highest level (exceeding even that of the control) when G-CSF was injected at 3:00 a.m. Dosing times of both chemotherapy and growth factor are relevant for optimization of carboplatin's hematologic tolerability. | lld:pubmed |
| pubmed-article:9654113 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9654113 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654113 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9654113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654113 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9654113 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9654113 | pubmed:issn | 0344-5704 | lld:pubmed |
| pubmed-article:9654113 | pubmed:author | pubmed-author:WolfsonSS | lld:pubmed |
| pubmed-article:9654113 | pubmed:author | pubmed-author:PelegLL | lld:pubmed |
| pubmed-article:9654113 | pubmed:author | pubmed-author:AshkenaziI... | lld:pubmed |
| pubmed-article:9654113 | pubmed:author | pubmed-author:RonI GIG | lld:pubmed |
| pubmed-article:9654113 | pubmed:author | pubmed-author:TicherAA | lld:pubmed |
| pubmed-article:9654113 | pubmed:author | pubmed-author:DotanAA | lld:pubmed |
| pubmed-article:9654113 | pubmed:author | pubmed-author:RiensteinSS | lld:pubmed |
| pubmed-article:9654113 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9654113 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:9654113 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9654113 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9654113 | pubmed:pagination | 135-41 | lld:pubmed |
| pubmed-article:9654113 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:meshHeading | pubmed-meshheading:9654113-... | lld:pubmed |
| pubmed-article:9654113 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9654113 | pubmed:articleTitle | Time dependency of hematopoietic growth factor coupled to chronotoxicity of carboplatin. | lld:pubmed |
| pubmed-article:9654113 | pubmed:affiliation | Department of Human Genetics, Sackler Faculty of Medicine, Tel-Aviv University, Israel. | lld:pubmed |
| pubmed-article:9654113 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9654113 | lld:pubmed |
