| pubmed-article:9632783 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C0068838 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1538064 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:9632783 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:9632783 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9632783 | pubmed:dateCreated | 1998-7-16 | lld:pubmed |
| pubmed-article:9632783 | pubmed:abstractText | In Neurospora crassa, the major nitrogen regulatory protein, NIT2, a member of the GATA family of transcription factors, controls positively the expression of numerous genes which specify nitrogen catabolic enzymes. Expression of the highly regulated structural gene nit-3, which encodes nitrate reductase, is dependent upon a synergistic interaction of NIT2 with a pathway-specific control protein, NIT4, a member of the GAL4 family of fungal regulatory factors. The NIT2 and NIT4 proteins both bind at specific recognition elements in the nit-3 promoter, but, in addition, we show that a direct protein-protein interaction between NIT2 and NIT4 is essential for optimal expression of the nit-3 structural gene. Neurospora possesses at least five different GATA factors which control different areas of cellular function, but which have a similar DNA binding specificity. Significantly, only NIT2, of the several Neurospora GATA factors examined, interacts with NIT4. We propose that protein-protein interactions of the individual GATA factors with additional pathway-specific regulatory factors determine each of their specific regulatory functions. | lld:pubmed |
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| pubmed-article:9632783 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9632783 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9632783 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9632783 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9632783 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:9632783 | pubmed:author | pubmed-author:MarzlufG AGA | lld:pubmed |
| pubmed-article:9632783 | pubmed:author | pubmed-author:FengBB | lld:pubmed |
| pubmed-article:9632783 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9632783 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9632783 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9632783 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9632783 | pubmed:pagination | 3983-90 | lld:pubmed |
| pubmed-article:9632783 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9632783 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9632783 | pubmed:articleTitle | Interaction between major nitrogen regulatory protein NIT2 and pathway-specific regulatory factor NIT4 is required for their synergistic activation of gene expression in Neurospora crassa. | lld:pubmed |
| pubmed-article:9632783 | pubmed:affiliation | Department of Biochemistry and Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, Ohio 43210, USA. | lld:pubmed |
| pubmed-article:9632783 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9632783 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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