| pubmed-article:9632570 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9632570 | lifeskim:mentions | umls-concept:C0079488 | lld:lifeskim |
| pubmed-article:9632570 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:9632570 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:9632570 | lifeskim:mentions | umls-concept:C0010868 | lld:lifeskim |
| pubmed-article:9632570 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:9632570 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:9632570 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:9632570 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9632570 | pubmed:dateCreated | 1998-7-9 | lld:pubmed |
| pubmed-article:9632570 | pubmed:abstractText | Broth culture supernatants from Tox+ Helicobacter pylori strains induce vacuolation of HeLa cells in vitro and contain VacA in concentrations that are higher than those found in supernatants from Tox- H. pylori strains. To investigate the basis for this phenomenon, we analyzed the transcription of the vacuolating cytotoxin gene (vacA) in eight Tox+ strains (each with a type s1/m1 vacA genotype) and nine Tox- strains (each with a type s2/m2 vacA genotype). Most of the Tox+ and Tox- strains tested used the same vacA transcriptional start point, but Tox+ strains yielded significantly stronger primer extension signal intensities than did Tox- strains (mean densitometry values of 15.8 +/- 1.9 versus 8.9 +/- 1.7, P = 0. 0016). Correspondingly, when we introduced vacA::xylE transcriptional fusions into the chromosomes of a Tox+ strain (60190) and a Tox- strain (86-313), the level of XylE activity in 60190 vacA::xylE was about 30-fold higher than that in 86-313 vacA::xylE. Sequence analysis and promoter exchange experiments indicated that the different levels of vacA transcription in these two strains cannot be explained solely by a difference in promoter strength. These data indicate that Tox+ and Tox- H. pylori strains typically differ not only in the VacA amino acid sequence but also in the level of vacA transcription. | lld:pubmed |
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| pubmed-article:9632570 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9632570 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9632570 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9632570 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9632570 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9632570 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:9632570 | pubmed:author | pubmed-author:BlaserM JMJ | lld:pubmed |
| pubmed-article:9632570 | pubmed:author | pubmed-author:AthertonJ CJC | lld:pubmed |
| pubmed-article:9632570 | pubmed:author | pubmed-author:CoverT LTL | lld:pubmed |
| pubmed-article:9632570 | pubmed:author | pubmed-author:ForsythM HMH | lld:pubmed |
| pubmed-article:9632570 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9632570 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:9632570 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9632570 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9632570 | pubmed:pagination | 3088-94 | lld:pubmed |
| pubmed-article:9632570 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9632570 | pubmed:meshHeading | pubmed-meshheading:9632570-... | lld:pubmed |
| pubmed-article:9632570 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9632570 | pubmed:articleTitle | Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains. | lld:pubmed |
| pubmed-article:9632570 | pubmed:affiliation | Departments of Medicine and Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. | lld:pubmed |
| pubmed-article:9632570 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9632570 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9632570 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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