Linked Life Data

9626354

Source:http://linkedlifedata.com/resource/pubmed/id/9626354

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9626354rdf:typepubmed:Citationlld:pubmed
pubmed-article:9626354lifeskim:mentionsumls-concept:C0019348lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C0439849lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C0022567lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C0205064lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C1510411lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C0205282lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C0205360lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C1158478lld:lifeskim
pubmed-article:9626354lifeskim:mentionsumls-concept:C1705422lld:lifeskim
pubmed-article:9626354pubmed:issue6lld:pubmed
pubmed-article:9626354pubmed:dateCreated1998-6-25lld:pubmed
pubmed-article:9626354pubmed:abstractTextTransfection of the right end Xho2 subfragment of Bg/II N of herpes simplex virus-2 (HSV-2) into human genital keratinocytes immortalized by human papillomavirus (HPV) type 16 or 18 resulted in invasive and noninvasive indolent cystic squamous carcinomas when cells were injected into immunocompromised mice. Retention and expression of the right end portion of the Bg/II N fragment correlated with malignancy, as the corresponding HSV-2 sequences were integrated and transcribed in the tumorigenic cell lines. HPV-immortalized cells alone were not tumorigenic. In contrast, previous results have shown that using the entire Bg/II N region can malignantly transform HPV-immortalized cells, although HSV2 DNA was not retained. Together, these observations localize the transforming activity of Bg/II N to Xho2 and suggest that the remaining sequences have an inhibitory effect on stable integration. The Xho2 sequence is 2480 bp long and contains an open reading frame (ORF) extending from nucleotides 559 to 1797. The ORF encodes a putative protein of 412-aa with a m.w. of 42-43 kDa and is highly homologous to UL43 of HSV-I. The correlation of tumorigenicity with stable integration and expression of Xho2 DNA in HPV-immortalized cells indicates that HSV-2 should be investigated further for a possible role in cervical cancer.lld:pubmed
pubmed-article:9626354pubmed:languageenglld:pubmed
pubmed-article:9626354pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9626354pubmed:citationSubsetIMlld:pubmed
pubmed-article:9626354pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9626354pubmed:statusMEDLINElld:pubmed
pubmed-article:9626354pubmed:monthJunlld:pubmed
pubmed-article:9626354pubmed:issn0020-7136lld:pubmed
pubmed-article:9626354pubmed:authorpubmed-author:DiPaoloJ AJAlld:pubmed
pubmed-article:9626354pubmed:authorpubmed-author:KessousAAlld:pubmed
pubmed-article:9626354pubmed:authorpubmed-author:BryantJJlld:pubmed
pubmed-article:9626354pubmed:authorpubmed-author:WoodworthC...lld:pubmed
pubmed-article:9626354pubmed:authorpubmed-author:CoutléeFFlld:pubmed
pubmed-article:9626354pubmed:authorpubmed-author:ZimonicD BDBlld:pubmed
pubmed-article:9626354pubmed:issnTypePrintlld:pubmed
pubmed-article:9626354pubmed:day10lld:pubmed
pubmed-article:9626354pubmed:volume76lld:pubmed
pubmed-article:9626354pubmed:ownerNLMlld:pubmed
pubmed-article:9626354pubmed:authorsCompleteYlld:pubmed
pubmed-article:9626354pubmed:pagination865-71lld:pubmed
pubmed-article:9626354pubmed:dateRevised2007-7-24lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:meshHeadingpubmed-meshheading:9626354-...lld:pubmed
pubmed-article:9626354pubmed:year1998lld:pubmed
pubmed-article:9626354pubmed:articleTitleRelationship of stable integration of herpes simplex virus-2 Bg/II N subfragment Xho2 to malignant transformation of human papillomavirus-immortalized cervical keratinocytes.lld:pubmed
pubmed-article:9626354pubmed:affiliationDivision of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda 20892, USA. dipaoloj@37a.nci.nih.govlld:pubmed
pubmed-article:9626354pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9626354pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed