| pubmed-article:9607925 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9607925 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9607925 | lifeskim:mentions | umls-concept:C0259309 | lld:lifeskim |
| pubmed-article:9607925 | lifeskim:mentions | umls-concept:C0035253 | lld:lifeskim |
| pubmed-article:9607925 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9607925 | pubmed:dateCreated | 1998-7-1 | lld:pubmed |
| pubmed-article:9607925 | pubmed:abstractText | 4-1BB ligand (4-1BBL) is a member of the tumor necrosis factor (TNF) family expressed on activated antigen-presenting cells. Its receptor, 4-1BB, is a member of the TNF receptor family expressed on activated CD4 and CD8 T cells. We have produced a soluble form of 4-1BBL using the baculovirus expression system. When coimmobilized on plastic with anti-CD3, soluble 4-1BBL induces interleukin (IL)-2 production by resting CD28+ or CD28- T cells, indicating that 4-1BBL can function independently of other cell surface molecules, including CD28, in costimulation of resting T cell activation. At low concentrations of anti-CD3, 4-1BBL is inferior to anti-CD28 in T cell activation. However, when 4-1BB ligand is provided together with strong TCR signals, then 4-1BBL and anti-CD28 are equally potent in stimulation of IL-2 production by resting T cells. We find that TNF receptor-associated factor (TRAF)1 or TRAF2 associate with a glutathione S-transferase-4-1BB cytoplasmic domain fusion protein in vitro. In T cells, we find that association of TRAF1 and TRAF2 with 4-1BB requires 4-1BB cross-linking. In support of a functional role for TRAF2 in 4-1BB signaling, we find that resting T cells isolated from TRAF2-deficient mice or from mice expressing a dominant negative form of TRAF2 fail to augment IL-2 production in response to soluble 4-1BBL. Thus 4-1BB, via the TRAF2 molecule, can provide CD28-independent costimulatory signals to resting T cells. | lld:pubmed |
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| pubmed-article:9607925 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9607925 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9607925 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9607925 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9607925 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9607925 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9607925 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:WattsT HTH | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:MaoT STS | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:LeeS YSY | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:ChoiYY | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:YeeW HWH | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:SantanaAA | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:GoldsteinM... | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:DeBenedetteM... | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:BangiaNN | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:SaoulliKK | lld:pubmed |
| pubmed-article:9607925 | pubmed:author | pubmed-author:CannonsJ LJL | lld:pubmed |
| pubmed-article:9607925 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9607925 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9607925 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:9607925 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9607925 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9607925 | pubmed:pagination | 1849-62 | lld:pubmed |
| pubmed-article:9607925 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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