| pubmed-article:9600971 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C0290149 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C0026255 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C1706968 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C0237477 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C1655807 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C1517499 | lld:lifeskim |
| pubmed-article:9600971 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:9600971 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9600971 | pubmed:dateCreated | 1998-6-22 | lld:pubmed |
| pubmed-article:9600971 | pubmed:abstractText | The antitumoral effects that follow the local delivery of the N-terminal fragment of human plasminogen (angiostatin K3) have been studied in two xenograft murine models. Angiostatin delivery was achieved by a defective adenovirus expressing a secretable angiostatin K3 molecule from the cytomegalovirus promoter (AdK3). In in vitro studies, AdK3 selectively inhibited endothelial cell proliferation and disrupted the G2/M transition induced by M-phase-promoting factors. AdK3-infected endothelial cells showed a marked mitosis arrest that correlated with the down-regulation of the M-phase phosphoproteins. A single intratumoral injection of AdK3 into preestablished rat C6 glioma or human MDA-MB-231 breast carcinoma grown in athymic mice was followed by a significant arrest of tumor growth, which was associated with a suppression of neovascularization within and at the vicinity of the tumors. AdK3 therapy also induced a 10-fold increase in apoptotic tumor cells as compared with a control adenovirus. Furthermore, we showed that systemic injection of AdK3 delayed C6 tumor establishment and growth, confirming that angiostatin can function in a paracrin manner. Our data support the concept that targeted antiangiogenesis, using adenovirus-mediated gene transfer, represents a promising alternative strategy for delivering antiangiogenic factors as their bolus injections present unsolved pharmacological problems. | lld:pubmed |
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| pubmed-article:9600971 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9600971 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9600971 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9600971 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9600971 | pubmed:month | May | lld:pubmed |
| pubmed-article:9600971 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:SoriaJJ | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:OpolonPP | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:SmithG GGG | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:PerricaudetMM | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:LuHH | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:LiHH | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:YehPP | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:GriscelliFF | lld:pubmed |
| pubmed-article:9600971 | pubmed:author | pubmed-author:Bennaceur-Gri... | lld:pubmed |
| pubmed-article:9600971 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9600971 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:9600971 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9600971 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9600971 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9600971 | pubmed:pagination | 6367-72 | lld:pubmed |
| pubmed-article:9600971 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:9600971 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9600971 | pubmed:articleTitle | Angiostatin gene transfer: inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest. | lld:pubmed |
| pubmed-article:9600971 | pubmed:affiliation | le Centre National de la Recherche Scientifique Unite de Recherche Associée 1301/Rhône-Poulenc Rorer Gencell, Institut Gustave Roussy, 94805 Villejuif, France. grisceli@igr.fr | lld:pubmed |
| pubmed-article:9600971 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9600971 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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