| pubmed-article:9597751 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9597751 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:9597751 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:9597751 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9597751 | lifeskim:mentions | umls-concept:C1413706 | lld:lifeskim |
| pubmed-article:9597751 | lifeskim:mentions | umls-concept:C1155589 | lld:lifeskim |
| pubmed-article:9597751 | lifeskim:mentions | umls-concept:C1948027 | lld:lifeskim |
| pubmed-article:9597751 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9597751 | pubmed:dateCreated | 1998-7-15 | lld:pubmed |
| pubmed-article:9597751 | pubmed:abstractText | Several endocrine and neuronal functions are governed by the cAMP-dependent pathway. Transcriptional regulation upon stimulation of this pathway is mediated by a family of cAMP-responsive nuclear factors. This family consists of a large number of members, which may act as activators or repressors. These factors contain the basic domain/leucine zipper motifs and bind as dimers to cAMP-response elements (CRE). CRE-binding protein (CREBs) function is modulated by phosphorylation by several kinases. Direct activation of gene expression by CREB requires phosphorylation by the cAMP-dependent PKA to serine 133. Among the repressors, ICER (Inducible cAMP Early Repressor) deserves special mention. ICER is generated from an alternative CREM promoter and is the only inducible CRE-binding protein. ICER negatively autoregulates the alternative promoter, generating a feedback loop. ICER expression is tissue specific and developmentally regulated. The kinetics of ICER expression are characteristic of an early response gene. CREM plays a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. The transcriptional activator CREM is highly expressed in postmeiotic cells. The role of CREM in spermiogenesis was addressed using CREM knock-out mice. Spermatogenesis stops at the first step of spermiogenesis in the mutants and there is a significant increase in apoptotic germ cells. This phenotype is reminiscent of cases of human infertility. ICER is regulated in a circadian manner in the pineal gland, the site of the hormone melatonin production. This night-day oscillation is driven by the endogenous clock (located in the suprachiasmatic nucleus). The synthesis of melatonin is regulated by a rate-limiting enzyme, serotonin N-acetyltransferase (NAT). Analysis of the CREM-null mice and of the promoter of the NAT gene revealed that ICER controls the amplitude and rhythmicity of NAT, and thus the oscillation in the hormonal synthesis of melatonin. | lld:pubmed |
| pubmed-article:9597751 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9597751 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9597751 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9597751 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9597751 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9597751 | pubmed:issn | 1357-2725 | lld:pubmed |
| pubmed-article:9597751 | pubmed:author | pubmed-author:Sassone-Corsi... | lld:pubmed |
| pubmed-article:9597751 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9597751 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:9597751 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9597751 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9597751 | pubmed:pagination | 27-38 | lld:pubmed |
| pubmed-article:9597751 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:9597751 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9597751 | pubmed:articleTitle | Coupling gene expression to cAMP signalling: role of CREB and CREM. | lld:pubmed |
| pubmed-article:9597751 | pubmed:affiliation | Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, C.U. de Strasbourg, France. | lld:pubmed |
| pubmed-article:9597751 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9597751 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:9597751 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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