| pubmed-article:9595484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9595484 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9595484 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:9595484 | lifeskim:mentions | umls-concept:C0079281 | lld:lifeskim |
| pubmed-article:9595484 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:9595484 | lifeskim:mentions | umls-concept:C0431109 | lld:lifeskim |
| pubmed-article:9595484 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:9595484 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:9595484 | pubmed:dateCreated | 1998-7-17 | lld:pubmed |
| pubmed-article:9595484 | pubmed:abstractText | Choroid plexus carcinoma is a rare neoplasm derived from the epithelium of the choroid plexus. The production and secretion of endothelin-1 (ET-1) by cultured human choroid plexus carcinoma cells were studied by radioimmunoassay and Northern blot analysis. Immunoreactive (IR)-ET was detected in the culture medium (2.78 +/- 0.12 fmol/10(5) cells/24 h; n = 5; mean +/- SEM) but not in the unconditioned medium. Reverse-phase high-performance liquid chromatography of the extract of the culture medium showed a single peak eluting in the position of ET-1. Treatment with tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) or a combination of interferon-gamma (IFN-gamma), TNF-alpha, and IL-1 beta caused significant increases in the IR-ET levels in the culture medium. Northern blot analysis of total RNA showed the expression of ET-1 mRNA in choroid plexus carcinoma cells. The expression levels of ET-1 mRNA were increased by treatment with a combination of IFN-gamma, TNF-alpha, and IL-1 beta. The present study has shown the production and secretion of ET-1 by cultured human choroid plexus carcinoma cells and suggests the possibility that ET-1 formation is related to the pathophysiology of this tumor. | lld:pubmed |
| pubmed-article:9595484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9595484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9595484 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9595484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9595484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9595484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9595484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9595484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9595484 | pubmed:issn | 0160-2446 | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:TakahashiKK | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:YoshimotoTT | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:HaraEE | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:ShibaharaSS | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:TominagaTT | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:KayamaTT | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:SatohFF | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:MurakamiOO | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:SongKK | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:KumabeTT | lld:pubmed |
| pubmed-article:9595484 | pubmed:author | pubmed-author:TotsuneKK | lld:pubmed |
| pubmed-article:9595484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9595484 | pubmed:volume | 31 Suppl 1 | lld:pubmed |
| pubmed-article:9595484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9595484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9595484 | pubmed:pagination | S367-9 | lld:pubmed |
| pubmed-article:9595484 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:meshHeading | pubmed-meshheading:9595484-... | lld:pubmed |
| pubmed-article:9595484 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9595484 | pubmed:articleTitle | Production and secretion of endothelin-1 by cultured choroid plexus carcinoma cells. | lld:pubmed |
| pubmed-article:9595484 | pubmed:affiliation | Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Japan. | lld:pubmed |
| pubmed-article:9595484 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9595484 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9595484 | lld:pubmed |
