Linked Life Data

9584201

Source:http://linkedlifedata.com/resource/pubmed/id/9584201

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:9584201rdf:typepubmed:Citationlld:pubmed
pubmed-article:9584201lifeskim:mentionsumls-concept:C0376622lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C0205112lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C0242643lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C0035143lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C0040649lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C0086860lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C0162768lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C1514562lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C1546857lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C1556066lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C1619636lld:lifeskim
pubmed-article:9584201lifeskim:mentionsumls-concept:C1514873lld:lifeskim
pubmed-article:9584201pubmed:issue6lld:pubmed
pubmed-article:9584201pubmed:dateCreated1998-6-17lld:pubmed
pubmed-article:9584201pubmed:abstractTextChromosomal translocations in acute leukemia that affect the AML-1/CBFbeta transcription factor complex create dominant inhibitory proteins. However, the mechanisms by which these proteins act remain obscure. Here we demonstrate that the multidrug resistance 1 (MDR-1) promoter is a target for AML/ETO transcriptional repression. This repression is of basal, not activated, expression from the MDR-1 promoter and thus represents a new mechanism for AML/ETO function. We have defined two domains in AML/ETO that are required for repression of basal transcription from the MDR-1 promoter: a hydrophobic heptad repeat (HHR) motif and a conserved zinc finger (ZnF) domain termed the MYND domain. The HHR mediates formation of AML/ETO homodimers and AML/ETO-ETO heterodimers. Single serine substitutions at conserved cysteine residues within the predicted ZnFs also abrogate transcriptional repression. Finally, we observe that AML/ETO can also inhibit Ets-1 activation of the MDR-1 promoter, indicating that AML/ETO can disrupt both basal and Ets-1-dependent transcription. The fortuitous inhibition of MDR-1 expression in t(8;21)-containing leukemias may contribute to the favorable response of these patients to chemotherapeutic drugs.lld:pubmed
pubmed-article:9584201pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:languageenglld:pubmed
pubmed-article:9584201pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:citationSubsetIMlld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:9584201pubmed:statusMEDLINElld:pubmed
pubmed-article:9584201pubmed:monthJunlld:pubmed
pubmed-article:9584201pubmed:issn0270-7306lld:pubmed
pubmed-article:9584201pubmed:authorpubmed-author:SunDDlld:pubmed
pubmed-article:9584201pubmed:authorpubmed-author:HiebertS WSWlld:pubmed
pubmed-article:9584201pubmed:authorpubmed-author:SchuetzJJlld:pubmed
pubmed-article:9584201pubmed:authorpubmed-author:LutterbachBBlld:pubmed
pubmed-article:9584201pubmed:issnTypePrintlld:pubmed
pubmed-article:9584201pubmed:volume18lld:pubmed
pubmed-article:9584201pubmed:ownerNLMlld:pubmed
pubmed-article:9584201pubmed:authorsCompleteYlld:pubmed
pubmed-article:9584201pubmed:pagination3604-11lld:pubmed
pubmed-article:9584201pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:9584201pubmed:meshHeadingpubmed-meshheading:9584201-...lld:pubmed
pubmed-article:9584201pubmed:meshHeadingpubmed-meshheading:9584201-...lld:pubmed
pubmed-article:9584201pubmed:meshHeadingpubmed-meshheading:9584201-...lld:pubmed
pubmed-article:9584201pubmed:meshHeadingpubmed-meshheading:9584201-...lld:pubmed
pubmed-article:9584201pubmed:meshHeadingpubmed-meshheading:9584201-...lld:pubmed
More...