| pubmed-article:9557652 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C0022568 | lld:lifeskim |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C0019340 | lld:lifeskim |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C0150108 | lld:lifeskim |
| pubmed-article:9557652 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:9557652 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:9557652 | pubmed:dateCreated | 1998-5-20 | lld:pubmed |
| pubmed-article:9557652 | pubmed:abstractText | Prior studies in our laboratory have suggested that the CC chemokine macrophage inflammatory protein-1alpha (MIP-1alpha) may be an important mediator in the blinding ocular inflammation which develops following herpes simplex virus type 1 (HSV-1) infection of the murine cornea. To directly test this hypothesis, MIP-1alpha-deficient (-/-) mice and their wild-type (+/+) counterparts were infected topically on the scarified cornea with 2.5 x 10(5) PFU of HSV-1 strain RE and subsequently graded for corneal opacity. Four weeks postinfection (p.i.), the mean corneal opacity score of -/- mice was 1.1 +/- 0.3 while that of the +/+ mice was 3.7 +/- 0.5. No detectable infiltrating CD4+ T cells were seen histologically at 14 or 21 days p.i. in -/- animals, whereas the mean CD4+ T-cell count per field (36 fields counted) in +/+ hosts was 26 +/- 2 (P < 0.001). In addition, neutrophil counts in the -/- mouse corneas were reduced by >80% in comparison to the wild-type controls. At 2 weeks p.i., no interleukin-2 or gamma interferon could be detected in six of seven -/- mice, whereas both T-cell cytokines were readily demonstrable in +/+ mouse corneas. Also, MIP-2 and monocyte chemoattractant protein-1 protein levels were significantly lower in MIP-1alpha -/- mouse corneas than in +/+ host corneas, suggesting that MIP-1alpha directly, or more likely indirectly, influences the expression of other chemokines. Interestingly, despite the paucity of infiltrating cells, HSV-1 clearance from the eyes of -/- mice was not significantly different from that observed in +/+ hosts. We conclude that MIP-1alpha is not needed to control virus growth in the cornea but is essential for the development of severe stromal keratitis. | lld:pubmed |
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| pubmed-article:9557652 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9557652 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9557652 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9557652 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9557652 | pubmed:month | May | lld:pubmed |
| pubmed-article:9557652 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:9557652 | pubmed:author | pubmed-author:SmithiesOO | lld:pubmed |
| pubmed-article:9557652 | pubmed:author | pubmed-author:LauschR NRN | lld:pubmed |
| pubmed-article:9557652 | pubmed:author | pubmed-author:ChoiN WNW | lld:pubmed |
| pubmed-article:9557652 | pubmed:author | pubmed-author:OakesJ EJE | lld:pubmed |
| pubmed-article:9557652 | pubmed:author | pubmed-author:ChengHH | lld:pubmed |
| pubmed-article:9557652 | pubmed:author | pubmed-author:TumpeyT MTM | lld:pubmed |
| pubmed-article:9557652 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9557652 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:9557652 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9557652 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9557652 | pubmed:pagination | 3705-10 | lld:pubmed |
| pubmed-article:9557652 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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