| pubmed-article:9556626 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9556626 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:9556626 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:9556626 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9556626 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
| pubmed-article:9556626 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:9556626 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:9556626 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:9556626 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:9556626 | pubmed:dateCreated | 1998-6-2 | lld:pubmed |
| pubmed-article:9556626 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:abstractText | We have characterized a group of cis-regulatory elements that control muscle-specific expression of the rat skeletal muscle type 1 sodium channel (SkM1) gene. These elements are located within a 3. 1-kilobase fragment that encompasses the 5'-flanking region, first exon, and part of the first intron of SkM1. We sequenced the region between -1062 and +311 and determined the start sites of transcription; multiple sites were identified between +1 and +30. The basal promoter (-65/+11) lacks cell-type specificity, while an upstream repressor (-174/-65) confers muscle-specific expression. A positive element (+49/+254) increases muscle-specific expression. Within these broad elements, two E boxes play a pivotal role. One E box at -31/-26 within the promoter, acting in part through its ability to bind the myogenic basic helix-loop-helix proteins, recruits additional factor(s) that bind elsewhere within the SkM1 sequence to control positive expression of the gene. A second E box at -90/-85 within the repressor controls negative regulation of the gene and acts through a different complex of proteins. Several of these cis-regulatory elements share both sequence and functional similarities with cis-regulatory elements of the acetylcholine receptor delta-subunit; the different arrangement of these elements may contribute to unique expression patterns for the two genes. | lld:pubmed |
| pubmed-article:9556626 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9556626 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9556626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9556626 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9556626 | pubmed:month | May | lld:pubmed |
| pubmed-article:9556626 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9556626 | pubmed:author | pubmed-author:BarchiR LRL | lld:pubmed |
| pubmed-article:9556626 | pubmed:author | pubmed-author:KallenR GRG | lld:pubmed |
| pubmed-article:9556626 | pubmed:author | pubmed-author:ReedR BRB | lld:pubmed |
| pubmed-article:9556626 | pubmed:author | pubmed-author:KranerS DSD | lld:pubmed |
| pubmed-article:9556626 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9556626 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:9556626 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9556626 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9556626 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9556626 | pubmed:pagination | 11327-34 | lld:pubmed |
| pubmed-article:9556626 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
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| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:meshHeading | pubmed-meshheading:9556626-... | lld:pubmed |
| pubmed-article:9556626 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9556626 | pubmed:articleTitle | Two E-boxes are the focal point of muscle-specific skeletal muscle type 1 Na+ channel gene expression. | lld:pubmed |
| pubmed-article:9556626 | pubmed:affiliation | Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA. kraner@mail.med.upenn.edu | lld:pubmed |
| pubmed-article:9556626 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9556626 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9556626 | lld:pubmed |
